Dexmedetomidine and Magnesium Sulfate: A Good Combination Treatment for Acute Lung Injury?

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dc.contributor.authorGuzel, Abdulmenap
dc.contributor.authorDogan, Erdal
dc.contributor.authorTurkcu, Gul
dc.contributor.authorKuyumcu, Mahir
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorCelik, Feyzi
dc.contributor.authorYildirim, Zeynep Baysal
dc.date.accessioned2024-04-24T16:24:40Z
dc.date.available2024-04-24T16:24:40Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: In this study, we aimed to investigate the therapeutic effects of magnesium sulfate (MgSO4) and dexmedetomidine (dex) in a model of acute lung injury (ALI). We determined whether concomitant administration decreased the inflammatory effects of hydrochloric acid (HCl)-induced ALI in a synergistic manner. Materials and Methods: In this study, 42 Sprague-Dawley rats were randomized into six groups: Group S (saline), Group SV (saline + mechanical ventilation), Group HCl (HCl), Group Dex (Dex), Group Mag (MgSO4), and Group DM (Dex + MgSO4). All groups except Group S were mechanically ventilated prior to HCl-induced ALI. Saline or HCl was administered via tracheostomy. Prior to treatment, HCl was administered to Group HCl, Group Dex, Group Mag, and Group DM to induce ALI. Dex and MgSO4 were administered intraperitoneally. The rats were monitored for 4 h after treatment to measure oxidative stress parameters in blood, and prolidase enzyme activity. Lung tissue damage were determined via histopathology. Results: A significant increase in heart rate and rapid desaturation was observed in HCl-administered groups. Treatment administration decreased the pulse values. Increased saturation values and decreased oxidative stress indices were observed in groups that were subsequently administered Dex and MgSO4. Serum prolidase activity increased significantly in Group HCl. Severe pathological findings were detected following HCl-induced ALI. Group Mag showed greater improvement in the pathology of HCl-induced ALI than did Group Dex. Administration of both Dex and MgSO4 did not improve the pathological scores. Conclusions: The antioxidant and anti-inflammatory effects of Dex and MgSO4 ameliorated the detrimental effects of HCI-induced ALI. However, adverse effects on hemodynamics and lung damage were observed when the two drugs were administered together.en_US
dc.description.sponsorshipDUBAP (Dicle University coordination committee of scientific research projects) [13 TF-08]en_US
dc.description.sponsorshipAuthors would like to thank the DUBAP (Dicle University coordination committee of scientific research projects) for scientific and financial support (Project number: 13 TF-08).en_US
dc.identifier.doi10.1080/08941939.2017.1422575
dc.identifier.endpage342en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue4en_US
dc.identifier.pmid29359990
dc.identifier.scopus2-s2.0-85041126693
dc.identifier.scopusqualityQ1
dc.identifier.startpage331en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2017.1422575
dc.identifier.urihttps://hdl.handle.net/11468/16810
dc.identifier.volume32en_US
dc.identifier.wosWOS:000472088700007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Lung Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectDexmedetomidineen_US
dc.subjectMagnesium Sulfateen_US
dc.titleDexmedetomidine and Magnesium Sulfate: A Good Combination Treatment for Acute Lung Injury?en_US
dc.titleDexmedetomidine and Magnesium Sulfate: A Good Combination Treatment for Acute Lung Injury?
dc.typeArticleen_US

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