Gene expression of ING4 gene in pancreatic cancers and splice forms of ING4 gene

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dc.contributor.authorYildirim, Ibrahim Halil
dc.contributor.authorCakmak, Ecir Ali
dc.contributor.authorCamci, Celaleddin
dc.date.accessioned2024-04-24T17:17:57Z
dc.date.available2024-04-24T17:17:57Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractPancreatic cancer is characterized by rapid metastasis and resistant to medical treatments. As the other cancers, mutations of tumor suppressor genes that involved in suppression of cell growth are observed in pancreatic cancers. ING4 protein is one of the proteins involved in the regulation of p53 tumor suppressor gene functions. ING4 involved in suppression of cell proliferation, chromosome rearrangement, cell migration, and angiogenesis. In this study, gene expressions and splicing variants of ING4 gene were investigated. Fresh tumor and normal specimens of the same pancreatic cancer patients were used. Gene expression study carried out by calculating the brightness of the bands on agarose gel and splicing variants were detected by direct sequencing. According to the results, three splice forms of ING4 and a decrease in gene expression of ING4 were determined. Splicing type of ING4 affects the translocation of ING4 proteins into the nucleus. To determine the gene expression of each splicing variant, will further clarify the role of ING4 in pancreatic cancers.en_US
dc.identifier.doi10.14715/cmb/2018.64.13.2
dc.identifier.endpage9en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue13en_US
dc.identifier.pmid30403588
dc.identifier.scopus2-s2.0-85056408061
dc.identifier.scopusqualityQ4
dc.identifier.startpage6en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2018.64.13.2
dc.identifier.urihttps://hdl.handle.net/11468/18473
dc.identifier.volume64en_US
dc.identifier.wosWOS:000449070100002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherC M B Assocen_US
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIng4en_US
dc.subjectAlternative Splicingen_US
dc.subjectGene Expressionen_US
dc.subjectP53en_US
dc.subjectPancreatic Canceren_US
dc.titleGene expression of ING4 gene in pancreatic cancers and splice forms of ING4 geneen_US
dc.titleGene expression of ING4 gene in pancreatic cancers and splice forms of ING4 gene
dc.typeArticleen_US

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