The effects of the thiolation with thioglycolic acid and L-cysteine on the mucoadhesion properties of the starch-graft-poly(acrylic acid)

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dc.contributor.authorGok, M. Koray
dc.contributor.authorDemir, Kamber
dc.contributor.authorCevher, Erdal
dc.contributor.authorOzsoy, Yildiz
dc.contributor.authorCirit, Umut
dc.contributor.authorBacinoglu, Suleyman
dc.contributor.authorOzgumus, Saadet
dc.date.accessioned2024-04-24T16:11:00Z
dc.date.available2024-04-24T16:11:00Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study is to investigate the effects of the thiolation on the mucoadhesion characteristics of the gelatinized and crosslinked wheat starch-graft-poly(acrylic acid) [(WS-g-PAA)(gc)] for potential use in drug delivery via vaginal route. Thiolation of (WS-g-PAA)(gc) was first time realized using L-cysteine hydrochloride monohydrate (CyS) and thioglycolic acid (TGA). These conjugates [(WS-g-PAA)(gcth)] were characterized using FTIR. The free SH group, mucoadhesion, cytotoxicity characteristics and the mechanism of the thiolation were also evaluated. To obtain fundamental data for possible application such as drug carrier, in vitro and in vivo progesterone release profiles from the mucoadhesive tablet formulations were also determined. The results showed that, vaginal tablet containing (WS-g-PAA)(gc)-TGA, which has not contain free SH groups in its structure, displays higher mucoadhesion than (WS-g-PAA)(gc) and (WS-g-PAA)(gc)-CyS. This tablet formulation can also be used as a drug carrier in vaginal applications. (C) 2017 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University [594/15122006, UDP-51789, BEK-21309, 8585]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Projects Coordination Unit of Istanbul University, Project Number 594/15122006, UDP-51789, BEK-21309 and 8585. Tablet formulation which was developed patented by the Turkish Patent Institute (TR 2012 03191 B, May 2015) and to be a patent applied the European Patent Office (19.03.2013-EP13160042.1). We would like to thank Institute of Aziz Sancar Experimental Medicine of Istanbul University for help in cytotoxicity assays.en_US
dc.identifier.doi10.1016/j.carbpol.2017.01.065
dc.identifier.endpage136en_US
dc.identifier.issn0144-8617
dc.identifier.issn1879-1344
dc.identifier.pmid28267489
dc.identifier.scopus2-s2.0-85010377746
dc.identifier.scopusqualityQ1
dc.identifier.startpage129en_US
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2017.01.065
dc.identifier.urihttps://hdl.handle.net/11468/15222
dc.identifier.volume163en_US
dc.identifier.wosWOS:000396955500015
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofCarbohydrate Polymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMucoadhesionen_US
dc.subjectStarchen_US
dc.subjectThiolationen_US
dc.subjectThioglycolic Aciden_US
dc.subjectL-Cysteineen_US
dc.subjectVaginal Tableten_US
dc.titleThe effects of the thiolation with thioglycolic acid and L-cysteine on the mucoadhesion properties of the starch-graft-poly(acrylic acid)en_US
dc.titleThe effects of the thiolation with thioglycolic acid and L-cysteine on the mucoadhesion properties of the starch-graft-poly(acrylic acid)
dc.typeArticleen_US

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