Ibrutinib: From molecule to medicine
Yükleniyor...
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
UHOD - Uluslararasi Hematoloji Onkoloji Dergisi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bruton’s tyrosine kinase (BTK) inhibitor Ibrutinib (PCI-32765) is a novel targeted-therapeutic agent modulating BCR, which serves as a covalent irreversible inhibitor of BTK. Ibrutinib significantly alters the composition of the tumor microenvironment in CLL, affecting soluble as well as cellular molecular elements without myelosupression. Ibrutinib is clinically developed as an orally administered anti-cancer agent with lead indications in relapse/refractory and in treatment-naïve patients with B-cell malignancies as a single agent. The clinical activities of Ibrutinib as a drug were shown in the B-cell malignancies, especially in patients with CLL, mantle cell lymphoma (MCL), and Waldenstrom’s macroglobulinemia (WM). Ibrutinib has generated the most extensive results so far in patients with CLL, predominately refractory or relapsed CLL where durable disease control as well as improved progression-free survival (PFS) and overall survival (OS) has been observed. The aim of this review is to outline the pharmacophysiological basis of Ibrutinib treatment as well as the current clinical experience based on the trials. The treatment algorithms of B-lymphoproliferative diseases will continue to be revised to a more personalized approach to treat with improved efficacy devoid of unnecessary toxicity.
Açıklama
Anahtar Kelimeler
BCR, BTK, CLL, Ibrutinib
Kaynak
UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
24
Sayı
3
Künye
Ayyıldız, O., Demirkan, F., Göker, H., Haznedaroğlu, İ. C., İlhan, O., Kaynar, L. G. ve diğerleri. (2014). Ibrutinib: From molecule to medicine. UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, 24(3), 4-14.
