Borderline ovarian tumors: clinical characteristics, management, and outcomes - a multicenter study

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dc.authorid0000-0002-3187-2317en_US
dc.authorid0000-0002-2325-1756en_US
dc.authorid0000-0002-0363-424Xen_US
dc.authorid0000-0002-7869-9662en_US
dc.authorid0000-0002-4215-1371en_US
dc.contributor.authorGökçü, Mehmet
dc.contributor.authorGüngördük, Kemal
dc.contributor.authorAşıcıoğlu, Osman
dc.contributor.authorÇetinkaya, Nilüfer
dc.contributor.authorGüngör, Tayfun
dc.contributor.authorPakay, Gonca
dc.contributor.authorAğaçayak, Elif
dc.date.accessioned2024-04-04T13:10:59Z
dc.date.available2024-04-04T13:10:59Z
dc.date.issued2016en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractBackground: The optimal surgical management and staging of borderline ovarian tumors (BOTs) are controversial. Institutions have different surgical approaches for the treatment of BOTs. Here, we performed a retrospective review of clinical characteristics, surgical management and surgical outcomes, and sought to identify variables affecting disease-free survival (DFS) and overall survival (OS) in patients with BOTs. Methods: A retrospective review of ten gynecological oncology department databases in Turkey was conducted to identify patients diagnosed with BOTs. The effects of type of surgery, age, stage, surgical staging, complete versus incomplete staging, and adjuvant chemotherapy were examined on DFS and OS. Results: In total, 733 patients with BOTs were included in the analysis. Most of the staged cases were in stage IA (70.4 %). In total, 345 patients underwent conservative surgeries. Recurrence rates were similar between the conservative and radical surgery groups (10.5 % vs. 8.7 %). Furthermore we did not find any difference between DFS (HR = 0.96; 95 % confidence interval, CI = 0.7-1.2; p = 0.576) or OS (HR = 0.9; 95 % CI = 0.8-1.1; p = 0.328) between patients who underwent conservative versus radical surgeries. There was also no difference in DFS (HR = 0.74; 95 % CI = 0.8-1.1; p = 0.080) or OS (HR = 0.8; 95 % CI = 0.7-1.0; p = 0.091) between complete, incomplete, and unstaged patients. Furthermore, receiving adjuvant chemotherapy (CT) for tumor stage ≥ IC was not an independent prognostic factor for DFS or OS. Conclusions: Patients undergoing conservative surgery did not show higher recurrence rates; furthermore, survival time was not shortened. Detailed surgical staging, including lymph node sampling or dissection, appendectomy, and hysterectomy, were not beneficial in the surgical management oF BOTs.en_US
dc.identifier.citationGokçü, M., Güngördük, K., Aşıcıoğlu, O., Çetinkaya, N., Güngör, T., Pakay, G. ve diğerleri. (2016). Borderline ovarian tumors: clinical characteristics, management, and outcomes - a multicenter study. Journal of Ovarian Research, 9(1), 1-8.en_US
dc.identifier.doi10.1186/s13048-016-0276-1
dc.identifier.endpage8en_US
dc.identifier.issn1757-2215
dc.identifier.issue1en_US
dc.identifier.pmid27756415
dc.identifier.scopus2-s2.0-84992316319
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-016-0276-1
dc.identifier.urihttps://hdl.handle.net/11468/13838
dc.identifier.volume9en_US
dc.identifier.wosWOS:000385879800002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAğaçayak, Elif
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofJournal of Ovarian Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdjuvant chemotherapyen_US
dc.subjectBorderline ovarian tumoren_US
dc.subjectSurgeryen_US
dc.titleBorderline ovarian tumors: clinical characteristics, management, and outcomes - a multicenter studyen_US
dc.titleBorderline ovarian tumors: clinical characteristics, management, and outcomes - a multicenter study
dc.typeArticleen_US

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