Morphological alterations in small intestine of rats with myenteric plexus denervation

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dc.contributor.authorDeniz, M
dc.contributor.authorKilinç, M
dc.contributor.authorHatipoglu, ES
dc.date.accessioned2024-04-24T17:14:26Z
dc.date.available2024-04-24T17:14:26Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe aimed to investigate the effect of myenteric denervation by benzalkonium chloride (BAC) on small intestine morphology in the rat, and whether segmental myenteric denervation alters morphology elsewhere in the small intestine. Forty male Sprague-Dawley rats were equally divided into 4 groups: control (0.9% NaCl); denervation (0.062% BAC); chemical inflammation (5% acetic acid), and intraluminal stasis produced by partial obstruction. 28 days after operation tissue samples were taken from the treated segment, 10 cm distal to the treated segment, and 20 cm proximal to the treated segment. Morphological changes and the number of ganglion cells were examined under the light microscope. BAC application reduced the number of myenteric neurons by 85% in the treated segment. Denervation increased villus height and crypt depth in the treated and proximal segments. But changes in muscle thickness were seen throughout the intestine. As a result, although myenteric plexus denervation caused mucosa morphology in the treated and proximal segments, it caused smooth muscle changes throughout the small intestine. Copyright (C) 2004 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000077257
dc.identifier.endpage158en_US
dc.identifier.issn0014-312X
dc.identifier.issue3en_US
dc.identifier.pmid15178904en_US
dc.identifier.scopus2-s2.0-2442629198en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage152en_US
dc.identifier.urihttps://doi.org/10.1159/000077257
dc.identifier.urihttps://hdl.handle.net/11468/17941
dc.identifier.volume36en_US
dc.identifier.wosWOS:000221244600005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofEuropean Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzalkonium Chlorideen_US
dc.subjectDenervationen_US
dc.subjectMyenteric Plexusen_US
dc.titleMorphological alterations in small intestine of rats with myenteric plexus denervationen_US
dc.typeArticleen_US

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