Effects of vector ultrasonic system debridement and conventional instrumentation on the levels of TNF-? in gingival crevicular fluid of patients with chronic periodontitis

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dc.contributor.authorArpag, Osman Fatih
dc.contributor.authorDag, Ahmet
dc.contributor.authorIzol, Bozan Serhat
dc.contributor.authorCimitay, Gulcan
dc.contributor.authorUysal, Ersin
dc.date.accessioned2024-04-24T17:18:14Z
dc.date.available2024-04-24T17:18:14Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground. Tumor necrosis factor alpha (TNF-alpha) is an inflammatory mediator whose levels are increased in the gingival crevicular fluid and blood serum in the case of chronic periodontitis. Objectives. The aim of this study was to determine the effect of vector ultrasonic system (VUS) on the levels of TNF-alpha in gingival crevicular fluid (GCF) and the clinical parameters in patients with chronic periodontitis. Material and methods. The study protocol was conducted using split-mouth design in 30 patients with chronic periodontitis. VUS and scaling and root planing (S/RP) were applied separately to 2 quadrants, including the upper and the lower jaws. At baseline and after 6 months, clinical parameters including plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL) were recorded, and concentrations of TNF-alpha in GCF were determined by enzyme-linked immunosorbent assay (ELISA). Intergroup comparisons were evaluated by the independent Students' t-test, and the Pearson correlation was used to determine the relationship between parameters. The level of significance was set at 5%. Results. Both treatment modalities provided statistically significant improvements in clinical periodontal parameters and TNF-alpha levels after 6 months (p < 0.05). Also, there were no significant correlations between the TNF-alpha levels in GCF and the clinical parameters in both treatment group at baseline and at the end of 6 months period (p > 0.05). Conclusions. The use of the vector ultrasonic system in the non-surgical treatment of chronic periodontitis presents beneficial improvements for the clinical attachment level and the probing pocket depth as well as TNF-alpha levels in GCF.en_US
dc.description.sponsorshipScientific Research Projects Agency, Coordination Unit of Dicle University, Diyarbakir, Turkeyen_US
dc.description.sponsorshipScientific Research Projects Agency, Coordination Unit of Dicle University, Diyarbakir, Turkey.en_US
dc.identifier.doi10.17219/acem/65410
dc.identifier.endpage1424en_US
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue9en_US
dc.identifier.pmid29442464
dc.identifier.scopus2-s2.0-85040011458
dc.identifier.scopusqualityQ1
dc.identifier.startpage1419en_US
dc.identifier.urihttps://doi.org/10.17219/acem/65410
dc.identifier.urihttps://hdl.handle.net/11468/18686
dc.identifier.volume26en_US
dc.identifier.wosWOS:000426592000014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances in Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNon-Surgical Periodontal Debridementen_US
dc.subjectTumor Necrosis Factor Alphaen_US
dc.subjectChronic Periodontitisen_US
dc.titleEffects of vector ultrasonic system debridement and conventional instrumentation on the levels of TNF-? in gingival crevicular fluid of patients with chronic periodontitisen_US
dc.titleEffects of vector ultrasonic system debridement and conventional instrumentation on the levels of TNF-? in gingival crevicular fluid of patients with chronic periodontitis
dc.typeArticleen_US

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