Toxic Effect of Cyclophosphamide on Sperm Morphology, Testicular Histology and Blood Oxidant-Antioxidant Balance, and Protective Roles of Lycopene and Ellagic Acid

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dc.contributor.authorCeribasi, Ali Osman
dc.contributor.authorTurk, Gaffari
dc.contributor.authorSonmez, Mustafa
dc.contributor.authorSakin, Fatih
dc.contributor.authorAtessahin, Ahmet
dc.date.accessioned2024-04-24T17:11:39Z
dc.date.available2024-04-24T17:11:39Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, the toxic effect of cyclophosphamide (CP) on sperm morphology, testicular histology and blood oxidant-antioxidant balance, and protective roles of lycopene (LC) and ellagic acid (EA) were investigated. For this purpose, 48 healthy, adult, male Sprague-Dawley rats were divided into six groups; eight animals in each group. The control group was treated with placebo. LC, EA and CP groups were given alone LC (10 mg/kg/every other day), EA (2 mg/kg/every other day) and CP (15 mg/kg/week) respectively. One of the last two groups received CP + LC, and the other treated with CP + EA. All treatments were maintained for 8 weeks. At the end of the treatment period, morphological abnormalities of sperm, plasma malondialdehyde (MDA) levels and glutathione (GSH) levels, and GSH-peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD) activities in erythrocytes, and testicular histopathological changes were examined. CP administration caused statistically significant increases in tail and total abnormality of sperm, plasma MDA level and erythrocyte SOD activity, and decreases in erythtocyte CAT activity, diameters of seminiferous tubules, germinal cell layer thickness and Johnsen's Testicular Score along with degeneration, necrosis, immature germ cells, congestion and atrophy in testicular tissue. However, LC or EA treatments to CP-treated rats markedly improved the CP-induced lipid peroxidation, and normalized sperm morphology and testicular histopathology. In conclusion, CP-induced lipid peroxidation leads to the structural damages in spermatozoa and testicular tissue of rats, and also LC or EA have a protective effect on these types of damage.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [106O123]en_US
dc.description.sponsorshipThe authors acknowledge for financial support from The Scientific and Technological Research Council of Turkey (TUBITAK); Project number: 106O123.en_US
dc.identifier.doi10.1111/j.1742-7843.2010.00571.x
dc.identifier.endpage736en_US
dc.identifier.issn1742-7835
dc.identifier.issue3en_US
dc.identifier.pmid20353483
dc.identifier.scopus2-s2.0-77955786918
dc.identifier.scopusqualityQ2
dc.identifier.startpage730en_US
dc.identifier.urihttps://doi.org/10.1111/j.1742-7843.2010.00571.x
dc.identifier.urihttps://hdl.handle.net/11468/17655
dc.identifier.volume107en_US
dc.identifier.wosWOS:000280999700005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleToxic Effect of Cyclophosphamide on Sperm Morphology, Testicular Histology and Blood Oxidant-Antioxidant Balance, and Protective Roles of Lycopene and Ellagic Aciden_US
dc.titleToxic Effect of Cyclophosphamide on Sperm Morphology, Testicular Histology and Blood Oxidant-Antioxidant Balance, and Protective Roles of Lycopene and Ellagic Acid
dc.typeArticleen_US

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