The efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer

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dc.contributor.authorTutanc, Oznur Donmez
dc.contributor.authorAydogan, Akin
dc.contributor.authorAkkucuk, Seckin
dc.contributor.authorSunbul, Ahmet Taner
dc.contributor.authorZincircioglu, Seyit Burhanedtin
dc.contributor.authorAlpagat, Gulistan
dc.contributor.authorErden, Ersin Sukru
dc.date.accessioned2024-04-24T17:24:56Z
dc.date.available2024-04-24T17:24:56Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim of the study: This study explores the efficacy of oral glutamine in the prevention of acute radiotherapy-induced esophagitis in patients with lung cancer who are treated with thoracic radiotherapy. Material and methods: This study was planned as a retrospective randomized experimental study. Forty-six patients with lung cancer, who were treated and kept under control between January 2008 and January 2010, were included in the study by the Department of Radiation Oncology, Faculty of Medicine, Dicle University. The patients were divided into two groups. The first group (n = 21) was given prophylactic oral powder glutamine (daily 30 g), while the second group (n = 25) was not given oral glutamine. Results: There were 21 patients in Group 1 (45.7%) and 25 patients in Group 2 (54.3%). No significant statistical difference was observed between the two groups in terms of age, gender, stage, histopathological type, treatment choice, received radiation doses, esophagus length in RI field, or location of the tumor (p > 0.05). A significant statistical difference was observed between the glutamine-supplemented group (first group) and the glutamine:free group (second group) according to the grade of esophagitis (p < 0.0001). Conclusions: In our retrospective randomized experimental study, we determined that the severity of acute radiotherapy-induced esophagitis might be decreased with oral glutamine in patients with lung Cancer who were treated with thoracic radiotherapy.en_US
dc.identifier.doi10.5114/wo.2013.38912
dc.identifier.endpage524en_US
dc.identifier.issn1428-2526
dc.identifier.issue6en_US
dc.identifier.pmid24592140
dc.identifier.scopus2-s2.0-84890897147
dc.identifier.scopusqualityQ2
dc.identifier.startpage520en_US
dc.identifier.urihttps://doi.org/10.5114/wo.2013.38912
dc.identifier.urihttps://hdl.handle.net/11468/19882
dc.identifier.volume17en_US
dc.identifier.wosWOS:000331993300009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofWspolczesna Onkologia-Contemporary Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Esophagitisen_US
dc.subjectLung Canceren_US
dc.subjectGlutamineen_US
dc.subjectThoracic Radiotherapyen_US
dc.subjectRadioprotectiveen_US
dc.titleThe efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung canceren_US
dc.titleThe efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer
dc.typeArticleen_US

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