Immunoexpression of vascular endothelial growth factor, ?-cell lymphoma 2 and cluster of differentiation 68 in cerebellar tissue of rats treated with Ganoderma lucidum

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dc.authorid0000-0001-7317-5467en_US
dc.authorid0000-0002-1967-4844en_US
dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorÖzevren, Hüseyin
dc.contributor.authorİrtegün, Sevgi
dc.contributor.authorEkingen, Arzu
dc.contributor.authorTuncer, Cudi Mehmet
dc.contributor.authorÖzkorkmaz, Ebru Gökalp
dc.contributor.authorDeveci, Engin
dc.contributor.authorDeveci, Şenay
dc.date.accessioned2022-08-10T07:35:04Z
dc.date.available2022-08-10T07:35:04Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalıen_US
dc.description.abstractTraumatic brain injury (TBI) can potentially lead to hemorrhages in all areas of the skull, which can damage cells andnerve connections. This study aims to investigate the protective effects of Ganoderma lucidum polysaccharides (GLPS) as a antioxidant oncerebellar cell tissues after traumatic brain injury in rats. Sprague Dawley rats were subjected to TBI with a weight-drop device using 300 g-1m weight-height impact. The groups are consisted of control, trauma, and trauma+Ganoderma lucidum groups. At seven days post-braininjury, experimental rats were decapitated after intraperitoneal administration of ketamine HCL (0.15 ml/100 g body weight). Cereballarsamples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels andmyeloperoxidase (MPO) activity. Significant improvement was observed in cells and vascular structures of Ganoderma lucidum treatedgroups when compared to untreated groups. It is believed that Ganoderma lucidum may have an effect on the progression of traumatic braininjury. Ganoderma lucidum application may affect angiogenetic development in blood vessel endothelial cells, decrease inflammatory cellaccumulation by affecting cytokine mechanism and may create apoptotic nerve cells and neuroprotective mechanism in glial cellsen_US
dc.identifier.citationÖzevren, H., İrtegün, S., Ekingen, A., Tuncer, C. M., Özkorkmaz, E. G. ve Deveci, E. (2018). Immunoexpression of vascular endothelial growth factor, β-cell lymphoma 2 and cluster of differentiation 68 in cerebellar tissue of rats treated with Ganoderma lucidum. International Journal of Morphology, 36(4), 1453-1462.en_US
dc.identifier.doi10.4067/S0717-95022018000401453en_US
dc.identifier.endpage1462en_US
dc.identifier.issn0717-9367
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85059301463en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1453en_US
dc.identifier.urihttps://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000401453&lng=en&nrm=iso&tlng=en
dc.identifier.urihttps://hdl.handle.net/11468/10157
dc.identifier.volume36en_US
dc.identifier.wosWOS:000454335600048
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖzevren, Hüseyin
dc.institutionauthorİrtegün, Sevgi
dc.institutionauthorTuncer, Cudi Mehmet
dc.institutionauthorÖzkorkmaz, Ebru Gökalp
dc.institutionauthorDeveci, Engin
dc.institutionauthorDeveci, Şenay
dc.language.isoenen_US
dc.publisherUniversidad de la Fronteraen_US
dc.relation.ispartofInternational Journal of Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectβcl-2en_US
dc.subjectCD68en_US
dc.subjectGanoderma lucidumen_US
dc.subjectTraumatic brain injuryen_US
dc.subjectCerebellumen_US
dc.subjectHistopathologyen_US
dc.subjectRaten_US
dc.titleImmunoexpression of vascular endothelial growth factor, ?-cell lymphoma 2 and cluster of differentiation 68 in cerebellar tissue of rats treated with Ganoderma lucidumen_US
dc.title.alternativeInmunoexpresión del factor de crecimiento endotelial vascular, linfoma de células ? 2 y grupo de diferenciación 68 en tejido cerebeloso de ratas tratadas con Ganoderma lucidumen_US
dc.typeArticleen_US

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