High levels of high-sensitivity C-reactive protein and impaired autonomic activity in smokers

Basit Öğe Kaydı
dc.contributor.authorAlyan, Omer
dc.contributor.authorKacmaz, Fehmi
dc.contributor.authorOzdemir, Ozcan
dc.contributor.authorKarahan, Zulkuf
dc.contributor.authorTaskesen, Tuncay
dc.contributor.authorIyem, Hikmet
dc.contributor.authorAlan, Sait
dc.date.accessioned2024-04-24T17:37:30Z
dc.date.available2024-04-24T17:37:30Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: We investigated the relationship between high sensitivity C-reactive protein (hs-CRP) activity and autonomic nervous activity using heart rate variability in smokers. Study design: The study consisted of 136 healthy subjects, including 66 smokers (35 women, 31 men; mean age 36 years) and 70 nonsmokers (43 women, 27 men; mean age 34 years). Serum samples were collected from all the subjects. Three-channel, 24-hr Holter monitoring was performed to derive the mean heart rate, standard deviation of normal NN intervals (SDNN), standard deviation of 5-minute mean NN intervals (SDANN), root mean square differences of successive NN intervals (RMSSD), high-(HF) and low-(LF) frequency power components, and the LF/HF ratio. Results: In smokers, the mean duration of smoking was 13.6 +/- 8.2 years (range 3 to 45 years), and the mean number of cigarettes consumed per day was 16.3 +/- 7.1 (range 5 to 40). Smokers exhibited significantly higher mean heart rate, hs-CRP and fibrinogen levels, mean platelet volume, white blood cell count, LF, and LF/HF ratio, with significantly lower SDNN, SDANN, RMSSD, and HF values. In smokers, hs-CRP was correlated with the number of cigarettes consumed per day, duration of smoking, fibrinogen level, mean platelet volume, white blood cell count, LF, and LF/HF ratio, and inversely correlated with HF, SDNN, and SDANN. Even smoking a single cigarette resulted in an acute, 0.07-fold increase in the hs-CRP level (p< 0.0001). In linear regression analysis, both the number of cigarettes consumed per day (beta= 0.52, p= 0.011) and duration of smoking (beta= 0.073, p< 0.0001) had an independent effect on the hs-CRP level. Conclusion: Smoking both impairs the sympathovagal balance and increases the hs-CRP activity in otherwise healthy smokers, the combination of which would probably contribute to a higher rate of cardiovascular events.en_US
dc.identifier.endpage375en_US
dc.identifier.issn1016-5169
dc.identifier.issue6en_US
dc.identifier.pmid19155639
dc.identifier.scopus2-s2.0-68849117093
dc.identifier.scopusqualityQ3
dc.identifier.startpage368en_US
dc.identifier.urihttps://hdl.handle.net/11468/20962
dc.identifier.volume36en_US
dc.identifier.wosWOS:000421433100002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isotren_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives of The Turkish Society of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-Reactive Protein/Analysisen_US
dc.subjectElectrocardiographyen_US
dc.subjectHeart Rate/Physiologyen_US
dc.subjectRisk Factorsen_US
dc.subjectSmoking/Adverse Effectsen_US
dc.subjectSympathetic Nervous System/Physiologyen_US
dc.titleHigh levels of high-sensitivity C-reactive protein and impaired autonomic activity in smokersen_US
dc.titleHigh levels of high-sensitivity C-reactive protein and impaired autonomic activity in smokers
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu