Serum cytokine levels in Behçet's disease

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dc.contributor.authorAkkurt, Zeynep Meltem
dc.contributor.authorBozkurt, Mehtap
dc.contributor.authorUçmak, Derya
dc.contributor.authorYüksel, Hatice
dc.contributor.authorUçak, Haydar
dc.contributor.authorSula, Bilal
dc.contributor.authorÖzkurt, Zeynep Gürsel
dc.contributor.authorYıldız, Mehmet
dc.contributor.authorAkdeniz, Dicle
dc.contributor.authorArıca, Mustafa
dc.contributor.orcid0000-0003-3742-6075
dc.date.accessioned2024-04-24T15:59:26Z
dc.date.available2024-04-24T15:59:26Z
dc.date.issued2015
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractBackgroundThe aim of this study is to investigate and compare the serum levels of various cytokines in patients with Behcet's Disease and healthy controls. MethodsThirty-five patients with Behcet's disease and 29 age and sex-matched healthy controls were included in the study. The patients were separated into groups with active and inactive disease. Serum IL-2, IL-6, IL-8, IL-10, IL-17A, and IFN- levels were determined using the enzyme-linked immunosorbent assay method. Cytokine levels of the two patient groups and healthy controls were compared using SPSS 15.0. ResultsTen patients with active disease and 25 patients with inactive disease were present. Serum IL-8 levels of active BD patients were higher compared to inactive patients (P = 0.048) and healthy controls (P = 0.02). IL-8 levels were correlated with the duration of symptoms (r = 0.490, P = 0.003) and time passed since diagnosis (r = 0.579, P ? 0.001). ConclusionBehcet's disease involves complex interactions of cells of the immune system, mainly T lymphocytes and neutrophils. Further studies on the cytokine profile in Behcet's disease will aid in elucidation of its pathogenesis.en_US
dc.description.sponsorshipDicle University Scientific Research Commissionen_US
dc.description.sponsorshipGrant sponsor: Dicle University Scientific Research Commission.en_US
dc.identifier.citationAkkurt, Z. M., Bozkurt, M., Uçmak, D., Yüksel, H., Uçak, H., Sula, B. ve diğerleri. (2015). Serum cytokine levels in Behçet's disease. Journal of Clinical Laboratory Analysis, 29(4), 317-320.
dc.identifier.doi10.1002/jcla.21772
dc.identifier.endpage320en_US
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.issue4en_US
dc.identifier.pmid25130392
dc.identifier.scopus2-s2.0-84937162566
dc.identifier.scopusqualityQ1
dc.identifier.startpage317en_US
dc.identifier.urihttps://doi.org/10.1002/jcla.21772
dc.identifier.urihttps://hdl.handle.net/11468/14060
dc.identifier.volume29en_US
dc.identifier.wosWOS:000358250300013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkkurt, Zeynep Meltem
dc.institutionauthorBozkurt, Mehtap
dc.institutionauthorUçmak, Derya
dc.institutionauthorYüksel, Hatice
dc.institutionauthorUçak, Haydar
dc.institutionauthorSula, Bilal
dc.institutionauthorÖzkurt, Zeynep Gürsel
dc.institutionauthorYıldız, Mehmet
dc.institutionauthorAkdeniz, Dicle
dc.institutionauthorArıca, Mustafa
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectInterleukin-8en_US
dc.titleSerum cytokine levels in Behçet's diseaseen_US
dc.titleSerum cytokine levels in Behçet's disease
dc.typeArticleen_US

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