Role of cited-1 and caspase-6 expression in HELLP syndrome

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dc.contributor.authorOcal, E.
dc.contributor.authorAkalin, S. Alkan
dc.contributor.authorAsir, F.
dc.date.accessioned2024-04-24T17:38:00Z
dc.date.available2024-04-24T17:38:00Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: In this study, we investigated the immunohistochemical staining of cited-1 and caspase-6 expression in the placentas of pregnant women with HELLP syndrome.PATIENTS AND METHODS: Placentas of 20 normotensive patients and 20 women with HELLP syndrome were processed for routine histological tissue processing. The biochemical and clinical parameters of patients were record-ed. Placentas were stained with hematoxylin-eosin and cited-1 and caspase-6 immunostaining.RESULTS: Placentas of normotensive patients showed normal histology. Placentas of women with HELLP syndrome showed degenerated cells, hyalinization and vacuolization. Cited-1 ex-pression was negative in normotensive group; however, it was increased in HELLP group, especially in decidual cells, endothelial cells and other placental cells. Caspase-6 expression was negative in placental structures of normotensive groups. However, it was intense in decidual cells, vacuolar and hyalinized areas, inflammatory cells and connective tissue cells in HELLP group.CONCLUSIONS: Cited-1 and caspase-6 are a marker in determining the severity of HELLP syndrome.en_US
dc.identifier.endpage3087en_US
dc.identifier.issn1128-3602
dc.identifier.issue7en_US
dc.identifier.pmid37070911
dc.identifier.scopus2-s2.0-85152973255
dc.identifier.scopusqualityQ2
dc.identifier.startpage3082en_US
dc.identifier.urihttps://hdl.handle.net/11468/21284
dc.identifier.volume27en_US
dc.identifier.wosWOS:000982646100014
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHellpen_US
dc.subjectPlacentaen_US
dc.subjectCited-1en_US
dc.subjectCaspase-6en_US
dc.titleRole of cited-1 and caspase-6 expression in HELLP syndromeen_US
dc.titleRole of cited-1 and caspase-6 expression in HELLP syndrome
dc.typeArticleen_US

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