GPR, King's Score and S-Index are superior to other non-invasive fibrosis markers in predicting the liver fibrosis in chronic Hepatitis B patients

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dc.authorid0000-0002-2677-3971en_US
dc.contributor.authorEkin, N.
dc.contributor.authorUçmak, F.
dc.contributor.authorEbik, B.
dc.contributor.authorTuncel, E. Tuğba
dc.contributor.authorKaçmaz, H.
dc.contributor.authorArpa, M.
dc.contributor.authorAtay, A. Engin
dc.date.accessioned2022-02-23T12:50:51Z
dc.date.available2022-02-23T12:50:51Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.descriptionWOS:000752376900001
dc.description.abstractBackground and study aims: In this study, we investigated the efficacy of nine non-invasive fibrosis markers in the assessment of the degree of fibrosis in patients with chronic Hepatitis B (CHB) in comparison with liver biopsy. Patients and methods: A total of 1454 untreated CHB patients from two different centers who underwent liver biopsy were included in the study. Laboratory results of patients were reviewed retrospectively and the pathology slides were re-evaluated in accordance with the Ishak score. Degree of fibrosis >_ 3 was accepted as "significant fibrosis", >_ 4 as "advanced fibrosis", and >_ 5 as cirrhosis. The diagnostic performance of the markers Aspartate aminotransferase to Platelet Ratio Index (APRI), Fibrosis-4 score (FIB-4), Aspartate aminotransferase to Alanine aminotransferase Ratio (AAR), AAR to Platelet Ratio Index (AAPRI), Gamma-glutamyl transpeptidase to Platelet Ratio (GPR), King's Score, Fibro quotient (Fibro-Q), S Index and Platelet to Lymphocyte Ratio (PLR) were evaluated with ROC analysis. Results: In detecting significant fibrosis, APRI, GPR, King's Score and S Index had AUROC values over 0.70. For advanced fibrosis, all of the models except AAPRI; and for cirrhosis, all of the models had AUROC values over 0.70. In accordance with the chosen staging system, GPR, King's Score and S Index had high diagnostic efficacy whereas APRI, FIB-4, FibroQ and PLR had moderate diagnostic efficacy, AAR and AAPRI had low diagnostic efficacy. Conclusions: GPR, King's Score and S Index had moderate diagnostic performance in detecting significant fibrosis and advanced fibrosis, and high diagnostic performance in detecting cirrhosis. (Acta gastroenterol. belg., 2022, 85, 62-68).en_US
dc.identifier.citationEkin, N., Uçmak, F., Ebik, B., Tuncel, E.T., Kaçmaz, H., Arpa, M. ve diğerleri. (2022). GPR, King's Score and S-Index are superior to other non-invasive fibrosis markers in predicting the liver fibrosis in chronic Hepatitis B patients. Acta Gastro-Enterologica Belgica, 85(1), 62-68.en_US
dc.identifier.doi10.51821/85.1.9156
dc.identifier.endpage68en_US
dc.identifier.issn1784-3227
dc.identifier.issue1en_US
dc.identifier.pmid35304995
dc.identifier.scopus2-s2.0-85125811093
dc.identifier.scopusqualityQ3
dc.identifier.startpage62en_US
dc.identifier.urihttps://hdl.handle.net/11468/9216
dc.identifier.volume85en_US
dc.identifier.wosWOS:000752376900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUçmak, F.
dc.language.isoenen_US
dc.publisherUniv Catholique Louvain-Uclclin Univ Saint Lucen_US
dc.relation.ispartofActa Gastro-Enterologica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitis Ben_US
dc.subjectLiver fibrosisen_US
dc.subjectNon-invasive fibrosis markersen_US
dc.titleGPR, King's Score and S-Index are superior to other non-invasive fibrosis markers in predicting the liver fibrosis in chronic Hepatitis B patientsen_US
dc.titleGPR, King's Score and S-Index are superior to other non-invasive fibrosis markers in predicting the liver fibrosis in chronic Hepatitis B patients
dc.typeArticleen_US

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