Gallstone Disease Does Not Predict Liver Histology in Nonalcoholic Fatty Liver Disease

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dc.contributor.authorYilmaz, Yusuf
dc.contributor.authorAyyildiz, Talat
dc.contributor.authorAkin, Hakan
dc.contributor.authorColak, Yasar
dc.contributor.authorOzturk, Oguzhan
dc.contributor.authorSenates, Ebubekir
dc.contributor.authorTuncer, Ilyas
dc.date.accessioned2024-04-24T17:24:49Z
dc.date.available2024-04-24T17:24:49Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground/Aims: We sought to examine whether the presence of gallstone disease (GD) in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD) is associated with liver fibrosis and histological nonalcoholic steatohepatitis (NASH) score. Methods: We included 441 Turkish patients with biopsy-proven NAFLD. GD was diagnosed in the presence of sonographic evidence of gallstones, echogenic material within the gallbladder with constant shadowing and little or no visualization of the gallbladder or absence of gallbladder at ultrasonography, coupled with a history of cholecystectomy. Results: Fifty-four patients (12.2%) had GD (GD+ subjects). Compared with the GD- subjects, GD+ patients were older, had a higher body mass index and were more likely to be female and have metabolic syndrome. However, GD+ patients did not have a higher risk of advanced fibrosis or definite NASH on histology. After adjustment for potential confounding variables, the prevalence of GD in NAFLD patients was not associated with significant fibrosis (>= 2) (odds ratio [OR], 1.06; 95% confidence interval [Cl], 0.53 to 2.21; p=0.68) or definite NASH (OR, 1.03; 95% Cl, 0.495 to 2.12; p=0.84). Conclusions: The presence of GD is not independently associated with advanced fibrosis and definite NASH in adult Turkish patients with biopsy-proven NAFLD.en_US
dc.identifier.doi10.5009/gnl.2014.8.3.313
dc.identifier.endpage317en_US
dc.identifier.issn1976-2283
dc.identifier.issn2005-1212
dc.identifier.issue3en_US
dc.identifier.pmid24827629
dc.identifier.scopus2-s2.0-84901237349
dc.identifier.scopusqualityQ1
dc.identifier.startpage313en_US
dc.identifier.urihttps://doi.org/10.5009/gnl.2014.8.3.313
dc.identifier.urihttps://hdl.handle.net/11468/19847
dc.identifier.volume8en_US
dc.identifier.wosWOS:000336008400013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEditorial Office Gut & Liveren_US
dc.relation.ispartofGut and Liver
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGallstone Diseaseen_US
dc.subjectNon-Alcoholic Fatty Liver Diseaseen_US
dc.subjectNonalcoholic Steatohepatitisen_US
dc.subjectFibrosisen_US
dc.titleGallstone Disease Does Not Predict Liver Histology in Nonalcoholic Fatty Liver Diseaseen_US
dc.titleGallstone Disease Does Not Predict Liver Histology in Nonalcoholic Fatty Liver Disease
dc.typeArticleen_US

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