Effects of melatonin on behavioral changes of neonatal rats in a model of cortical dysplasia

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dc.contributor.authorKaradeli, H. H.
dc.contributor.authorAktekin, B.
dc.contributor.authorYilmaz, B.
dc.contributor.authorKilic, E.
dc.contributor.authorUzar, E.
dc.contributor.authorAci, A.
dc.contributor.authorBingol, C. A.
dc.date.accessioned2024-04-24T17:33:42Z
dc.date.available2024-04-24T17:33:42Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: Cortical dysplasia (CD) is associated with several behavioral disorders in both the pediatric and the adult population. The effect of melatonin on behavioral disorders in rats generated CD has not been investigated so far. AIM: To investigate the effects of melatonin administration on activity and anxietic behavior of neonatal rats in a model of CD. MATERIALS AND METHODS: Newborn Sprague-Dawley rats (n=21) were randomized into three groups. On postnatal day 1, one freeze lesion was carried out in 14 rats between bregma and lambda to create a CD model. Another group of neonatal rats served as control group (n=7). Those 14 rats were either administered melatonin (n=7) or vehicle solution (n=7). Melatonin treatment (4 mg/kg/day, i.p.) was initiated ten days after induction of cold injury and continued for three weeks. Animal activity and anxiety were analyzed by using open field and elevated plus maze tests 24h after the last melatonin administration (day 32) in a blind manner. RESULTS: It was observed that CD induced animals spent significantly less time in the open field area when compared to the other groups (p < 0.01). Additionally, the time spent in the open field area was significantly elevated in the melatonin-treated animals compared to both the control and the CD groups (p < 0.01). Accordingly, anxiety scores in the CD group was significantly increased (p < 0.01), and this effect could be reversed by administration of melatonin. CONCLUSIONS: Melatonin exerts protective behavioral effects against cortical dysplasia in newborn rats. Further clinical investigations may prove melatonin as a useful therapeutic adjunct to prevent from possible behavioural damages of cortical dysplasia.en_US
dc.identifier.endpage2084en_US
dc.identifier.issn1128-3602
dc.identifier.issue15en_US
dc.identifier.pmid23884829
dc.identifier.scopus2-s2.0-84884215499
dc.identifier.scopusqualityQ2
dc.identifier.startpage2080en_US
dc.identifier.urihttps://hdl.handle.net/11468/20808
dc.identifier.volume17en_US
dc.identifier.wosWOS:000325204100012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectCortical Dysplasiaen_US
dc.subjectBehavioren_US
dc.titleEffects of melatonin on behavioral changes of neonatal rats in a model of cortical dysplasiaen_US
dc.titleEffects of melatonin on behavioral changes of neonatal rats in a model of cortical dysplasia
dc.typeArticleen_US

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