Prognostic importance of paraoxonase, arylesterase and mean platelet volume efficiency in acute ischaemic stroke

Basit Öğe Kaydı
dc.contributor.authorGokdemir, Mehmet Tahir
dc.contributor.authorKarakilcik, Ali Ziya
dc.contributor.authorGokdemir, Gul Sahika
dc.date.accessioned2024-04-24T17:37:50Z
dc.date.available2024-04-24T17:37:50Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To study the prognostic importance activity of paraoxonase and arylesterase, and the value of mean platelet volume in patients with acute ischaemic stroke. Methods: This case-control study was conducted at Harran University Hospital, Sanliurfa, Turkey, from January to June 2014, and comprised patients with symptoms of acute ischaemic stroke who presented to the emergency department. Paraoxonase activity, expressed in units per litre, or U/L, of serum, was evaluated in the absence of basal activity, and arylesterase activity was defined as micromoles, of phenol generated/min, and was expressed as U/L of serum. Mean platelet volume was measured as a routine parameter. SPSS 20 was used for data analysis. Results: Of the 94 participants, 48(51%) were patients with acute ischaemic stroke and 46(49%) were control subjects. Moreover, 27(56.3%) patients were females and 21(43.7%) were males. In the control group, 26(56.5%) were females and 20(43.5%) were males. The mean age of patients was 68.39 +/- 11.83 years compared to controls' 65 +/- 9.95 years. Decreased activity of prognostic importance and arylesterase were significant in patients than in the controls (p=0.016 and p=0.001, respectively). The median platelets of patients was significantly lower than that of the controls (p=0.004). However, the median mean platelet volume values were similar in the both groups (p=0.568). Binary logistic regression analyses showed that the paraoxonase and arylesterase were risk markers for the patients. Conclusion: Decreased paraoxonase and arylesterase activity and decreased platelet counts were observed probably due to increased oxidative stress in acute ischaemic stroke patients.en_US
dc.identifier.endpage1683en_US
dc.identifier.issn0030-9982
dc.identifier.issue11en_US
dc.identifier.pmid29171559
dc.identifier.scopus2-s2.0-85030973504
dc.identifier.scopusqualityQ3
dc.identifier.startpage1679en_US
dc.identifier.urihttps://hdl.handle.net/11468/21209
dc.identifier.volume67en_US
dc.identifier.wosWOS:000418462000009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPakistan Medical Assocen_US
dc.relation.ispartofJournal of The Pakistan Medical Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Ischemic Strokeen_US
dc.subjectParaoxonaseen_US
dc.subjectArylesteraseen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectEmergency Departmenten_US
dc.titlePrognostic importance of paraoxonase, arylesterase and mean platelet volume efficiency in acute ischaemic strokeen_US
dc.titlePrognostic importance of paraoxonase, arylesterase and mean platelet volume efficiency in acute ischaemic stroke
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu