Effect of caffeic acid phenethyl ester on myringosclerosis development in the tympanic membrane of rat

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dc.contributor.authorKinis, Vefa
dc.contributor.authorOzbay, Musa
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorGul, Aylin
dc.contributor.authorYilmaz, Beyhan
dc.contributor.authorOzkurt, Fazi Emre
dc.contributor.authorSengul, Engin
dc.date.accessioned2024-04-24T16:01:53Z
dc.date.available2024-04-24T16:01:53Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractMyringosclerosis is hyalinization and calcification of certain areas of the tympanic membrane, especially the fibrous lamina propria layer and appears as white sclerotic lesions. Ventilation tube insertion is one of the most performed operations in the pediatric otorhinolaryngology practice to treat chronic otitis media with effusion. Myringosclerosis is a very common sequela of ventilation tube insertion. In this experimental study, our aim was to show the histopathological effects of caffeic acid phenethyl ester on myringosclerosis development in rat tympanic membrane after myringotomy. The rats were randomly categorized into four experimental groups including the comparison group (n = 4), non-treated group (n = 7), the saline (control) group (n = 7), the caffeic acid phenethyl ester group (n = 7). Non-treated group did not receive any treatment for 15 days. Saline (2.5 mL/kg, intraperitoneal) was administered to the third group once a day for 15 days. Fourth group received caffeic acid phenethyl ester intraperitoneally once a day at a dose of 10 mu mol/kg for 15 days. Myringotomy was performed on the right tympanic membrane of all rats except comparison group using a sterile pick with the help of an operating microscope. Histopathological examination of myringosclerosis formation was done by a pathologist under light microscope. In histopathological analysis of groups, the severity of inflammation was milder in caffeic acid phenethyl ester group compared to non-treated and saline groups (p < 0.05). There was less myringosclerotic plaques in caffeic acid phenethyl ester group than in non-treated and saline groups (p < 0.05). TM thickness measurements were very close to each other in non-treated and saline groups. The tympanic membrane thickness of caffeic acid phenethyl ester group was much thinner than the other two groups (p < 0.05). Caffeic acid phenethyl ester decreases inflammation severity and the formation of myringosclerotic plaques. These two effects resulted in thinner tympanic membranes of rats which were treated with caffeic acid phenethyl ester. As a result, caffeic acid phenethyl ester has potential preventive effects on myringosclerosis development after myringotomy and ventilation tube insertion.en_US
dc.identifier.doi10.1007/s00405-013-2832-2
dc.identifier.endpage34en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue1en_US
dc.identifier.pmid24281567
dc.identifier.scopus2-s2.0-84943589198
dc.identifier.scopusqualityQ1
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-013-2832-2
dc.identifier.urihttps://hdl.handle.net/11468/14448
dc.identifier.volume272en_US
dc.identifier.wosWOS:000347292000006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectMyringosclerosisen_US
dc.subjectVentilation Tubeen_US
dc.subjectTympanic Membraneen_US
dc.subjectInflammationen_US
dc.subjectRaten_US
dc.titleEffect of caffeic acid phenethyl ester on myringosclerosis development in the tympanic membrane of raten_US
dc.titleEffect of caffeic acid phenethyl ester on myringosclerosis development in the tympanic membrane of rat
dc.typeArticleen_US

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