Design of an electrochemical sensing platform based on MoS2-PEDOT:PSS nanocomposite for the detection of epirubicin in biological samples

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dc.authorid0000-0002-5846-4436en_US
dc.contributor.authorEr, Engin
dc.contributor.authorAteş, Ali Kemal
dc.date.accessioned2023-09-29T05:52:03Z
dc.date.available2023-09-29T05:52:03Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractSynthesizing of two dimensional (2D)-based nanomaterial and its sensing platform design is an attractive approach for quantitative purposed electrochemical applications. In this work, for the first time, we synthesized the molybdenum disulphide (CE-MoS2) nanosheets exfoliated by metal intercalation method and followed by the modification of their surfaces with Poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) as a conductive polymer. The structural, morphological, and electrochemical characterization of CE-MoS2/PEDOT: PSS nanocomposite were performed by XPS, TGA, TEM and EIS. The portable electrochemical sensing platform was fabricated by the modification of CE-MoS2/PEDOT:PSS nanocomposite on screen-printed carbon electrode (SPCE). The electrochemical behaviour of epirubicin (EPB) was examined on SPCE modified with CE-MoS2/ PEDOT:PSS nanocomposite using cyclic and differential pulse voltammetry. CE-MoS2/PEDOT:PSS/SPCE demonstrated a promising electrocatalytic activity towards the oxidation of EPB, and analytical performance in the concentration range of 0.06 – 9.30 µM with a low detection limit of 44.3 nM. The human plasma samples containing EPB were successfully analyzed using CE-MoS2/PEDOT:PSS/SPCE with the satisfactory recoveries. The proposed sensing design could be an alternative strategy to produce the 2D-based nanoplatforms for electroanalytical applications in clinical samples.en_US
dc.identifier.citationEr, E. ve Ateş, A. K. (2023). Design of an electrochemical sensing platform based on MoS2-PEDOT:PSS nanocomposite for the detection of epirubicin in biological samples. Microchemical Journal, (189), 1-8.en_US
dc.identifier.doi10.1016/j.microc.2023.108534
dc.identifier.endpage8en_US
dc.identifier.issn0026-265X
dc.identifier.issue189en_US
dc.identifier.scopus2-s2.0-85148669602
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0026265X23001522?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/12628
dc.identifier.wosWOS:000965755100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAteş, Ali Kemal
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofMicrochemical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMoS2en_US
dc.subjectPEDOT:PSSen_US
dc.subjectElectrochemical sensoren_US
dc.subjectSurface modificationen_US
dc.subjectEpirubicinen_US
dc.titleDesign of an electrochemical sensing platform based on MoS2-PEDOT:PSS nanocomposite for the detection of epirubicin in biological samplesen_US
dc.titleDesign of an electrochemical sensing platform based on MoS2-PEDOT:PSS nanocomposite for the detection of epirubicin in biological samples
dc.typeArticleen_US

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