Multisystem inflammatory syndrome in children: A single-center experience

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dc.authorid0000-0001-8780-8122en_US
dc.authorid0000-0003-1587-9559en_US
dc.authorid0000-0001-5137-0501en_US
dc.authorid0000-0002-9232-5982en_US
dc.contributor.authorTüre, Mehmet
dc.contributor.authorKan, Ahmet
dc.contributor.authorAkın, Alper
dc.contributor.authorYılmaz, Kamil
dc.contributor.authorŞen, Velat
dc.date.accessioned2022-11-30T07:13:03Z
dc.date.available2022-11-30T07:13:03Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground This case series aims to evaluate the presenting symptoms, laboratory data, systemic findings, and response to early treatment in patients who were followed up with the diagnosis of multisystemic inflammatory syndrome associated with novel coronavirus disease 2019 (COVID-19). Methods The presentation, laboratory findings, and responses to treatment of patients hospitalized and diagnosed with multisystemic inflammatory syndrome were evaluated retrospectively. Results A total of 32 patients were included in the study. The median age was 90 (1.5-204) months and 62.5% of the patients were male; 59.4% of the cases were non-specific disease, 31.2% typical (complete) Kawasaki, and 9.4% had phenotypic characteristics of atypical (incomplete) Kawasaki. Most of the patients were found to have low albumin and elevated C-reactive protein, sedimentation rate, and d-dimer, and all patients had elevated N-terminal pro-B-type natriuretic peptide, and procalcitonin. Lymphopenia was detected in 25 patients (78.1%) and serum ferritin levels were elevated in 25 patients (78.1%). Eleven (34.4%) patients responded well only to intravenous immunoglobulin treatment. Twenty patients (62.5%) received intravenous immunoglobulin and steroid therapy (second-line therapy). Only one patient (3.1%) received third-line therapy (intravenous immunoglobulin + steroid +anakinra + plasmapheresis). None of the patients died. Conclusions Most patients had mild clinical symptoms and responded well to intravenous immunoglobulin and / or steroid therapies as first- and second-line therapies. Only one of our patients was clinically stabilized after third-line treatment because he did not respond to intravenous immunoglobulin and steroid therapy. We think that all of our patients diagnosed with multisystem inflammatory syndrome in children recovered because we had recommended quickly medical intervention. Treatment should therefore be started immediately in patients diagnosed with multisystem inflammatory syndrome in children. If there is no response after 24 h to the initial treatment, the next treatment protocol should be started.en_US
dc.identifier.citationTüre, M., Kan, A., Akın, A., Yılmaz, K. ve Şen, V. (2021). Multisystem inflammatory syndrome in children: A single-center experience. Pediatris International, 63(9), 1062-1068.en_US
dc.identifier.doi10.1111/ped.14742en_US
dc.identifier.endpage1068en_US
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue9en_US
dc.identifier.pmid34227711en_US
dc.identifier.scopus2-s2.0-85109114480en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1062en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/ped.14742
dc.identifier.urihttps://hdl.handle.net/11468/10899
dc.identifier.volume63en_US
dc.identifier.wosWOS:000669898500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTüre, Mehmet
dc.institutionauthorKan, Ahmet
dc.institutionauthorAkın, Alper
dc.institutionauthorYılmaz, Kamil
dc.institutionauthorŞen, Velat
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatris Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOVID 19en_US
dc.subjectMultisystem inflammatory syndromeen_US
dc.subjectPediatricsen_US
dc.titleMultisystem inflammatory syndrome in children: A single-center experienceen_US
dc.typeArticleen_US

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