Trauma Scores and Neuron-specific Enolase, Cytokine and C-reactive Protein Levels as Predictors of Mortality in Patients with Blunt Head Trauma

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dc.contributor.authorSogut, O.
dc.contributor.authorGuloglu, C.
dc.contributor.authorOrak, M.
dc.contributor.authorSayhan, M. B.
dc.contributor.authorGokdemir, M. T.
dc.contributor.authorUstundag, M.
dc.contributor.authorAkkus, Z.
dc.date.accessioned2024-04-24T17:14:43Z
dc.date.available2024-04-24T17:14:43Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study evaluated serum neuron-specific enolase (NSE), cytokine and high-sensitivity C-reactive-protein (hs-CRP) levels, along with the Glasgow Coma Scale (GCS) and Revised Trauma Score (RTS), as predictors of mortality in the early post-traumatic period, in 100 Turkish patients with blunt head trauma. Overall patient mortality was 27%. There was a significant association between age and mortality, and mortality was negatively correlated with GCS and RTS. Head injury severity (GCS) was significantly related to NSE, hs-CRP, interleukin (IL)-6, IL-8 and tumour necrosis factor (TNF)-alpha levels. Mortality correlated positively with IL-6, IL-8, TNF-alpha and hs-CRP levels. NSE, hs-CRP, IL-6, IL-8 and TNF-alpha levels were significantly higher in non-survivors compared with survivors. GCS score <= 8, younger age and NSE levels were significant independent predictors of mortality. During the early post-traumatic period, NSE may be an objective alternative criterion to the GCS, in the management of patients with blunt head trauma.en_US
dc.description.sponsorshipScientific Research Projects Committee of Dicle University, Diyarbakir, Turkeyen_US
dc.description.sponsorshipThe study was financially supported by the Scientific Research Projects Committee of Dicle University, Diyarbakir, Turkey and we should like to thank them for their contribution.en_US
dc.identifier.doi10.1177/147323001003800516
dc.identifier.endpage1720en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue5en_US
dc.identifier.pmid21309485
dc.identifier.scopus2-s2.0-78449291037
dc.identifier.scopusqualityQ2
dc.identifier.startpage1708en_US
dc.identifier.urihttps://doi.org/10.1177/147323001003800516
dc.identifier.urihttps://hdl.handle.net/11468/18157
dc.identifier.volume38en_US
dc.identifier.wosWOS:000285404000016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of International Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBlunt Head Traumaen_US
dc.subjectNeuron-Specific Enolaseen_US
dc.subjectCytokinesen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectGlasgow Coma Scaleen_US
dc.subjectRevised Trauma Scoreen_US
dc.titleTrauma Scores and Neuron-specific Enolase, Cytokine and C-reactive Protein Levels as Predictors of Mortality in Patients with Blunt Head Traumaen_US
dc.titleTrauma Scores and Neuron-specific Enolase, Cytokine and C-reactive Protein Levels as Predictors of Mortality in Patients with Blunt Head Trauma
dc.typeArticleen_US

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