Involvement of necroptosıs and apoptosıs ın protectıve effects of cyclosporın a on ischemıa-reperfusıon injury in rat kıdney

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dc.authorid0000-0002-3800-8767
dc.authorid0000-0001-6607-836X
dc.authorid0000-0002-0760-5681
dc.authorid0000-0001-5591-7607
dc.authorid0000-0003-4661-9784
dc.contributor.authorErdoğmuş, Zeynep Özgen
dc.contributor.authorErdi̇nç, Meral
dc.contributor.authorKaya, Meryem Şeyda
dc.contributor.authorAktar, Fesih
dc.contributor.authorÖzekinci, Selver Özşener
dc.contributor.authorErdinç, Levent
dc.contributor.authorUyar, Emre
dc.date.accessioned2025-02-22T14:09:06Z
dc.date.available2025-02-22T14:09:06Z
dc.date.issued2025
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bililmleri Bölümüen_US
dc.description.abstractWe aimed to investigate the protective effects of low dose cyclosporin A (CsA) on ischemia-reperfusion (IR) injury in rat the kidney and on the apoptotic and necroptotic mechanisms involved. 1. Control group (received a single intraperitoneal (i.p.) dose of 1 ml sterile saline 15 min before the surgical procedure), 2. IR group (was subjected to 30 min of bilateral kidney ischemia followed by 90 min of reperfusion; and received a single i.p. dose of 1 ml sterile saline 15 min before the IR procedure, 3. IR + CsA group (received a single i.p. dose of 3 mg/kg CsA 15 min before the IR procedure. Renal functions (renal perfusion pressures, and serum urea-creatinine levels), kidney histological scores, MDA levels, and TNF-alpha, caspase-3, RIP1, RIP3, MLKL, CaMKII and CypD protein expressions were also measured. Renal perfusion pressures (PP), serum urea and creatinine levels, renal tissue MDA levels, and the protein expression levels of TNF-alpha, caspase-3, RIP1, RIP3, MLKL, CAMKII and CypD were significantly increased in the IR group compared to the control group (p < 0.05), Additionally, there were significant decreases in all the parameters in the IR + CsA group compared to those in the IR group (p < 0.05). Furthermore, histopathological analyses revealed significantly higher kidney injury scores in the IR group compared to the control group, and low dose CsA treatment improved the injury. A single low dose of CsA injection 15 min before IR, demonstrated a protective effect on bilateral renal IR injury and a reduction in apoptotic and necroptopic markers which is resulted in improvement of renal functions.en_US
dc.description.sponsorshipDicle University Scientific Research Project Coordinator [ECZACILIK.20.006]en_US
dc.description.sponsorshipThe project was supported by the Dicle University Scientific Research Project Coordinator (with the number ECZACILIK.20.006).en_US
dc.identifier.citationÖzgen, Z. E., Erdinç, M., Kaya, M. Ş., Aktar, F., Özekinci, S. Ö., Erdinç, L. ve diğerleri. (2025). Involvement of necroptosıs and apoptosıs ın protectıve effects of cyclosporın a on ischemıa-reperfusıon injury in rat kidney. Journal of Molecular Histology, 56(1), 1-11.
dc.identifier.doi10.1007/s10735-024-10281-7
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue1en_US
dc.identifier.pmid39630315en_US
dc.identifier.scopus2-s2.0-85211170842en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-024-10281-7
dc.identifier.urihttps://hdl.handle.net/11468/29796
dc.identifier.volume56en_US
dc.identifier.wosWOS:001371412600002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErdoğmuş, Zeynep Özgen
dc.institutionauthorErdi̇nç, Meral
dc.institutionauthorKaya, Meryem Şeyda
dc.institutionauthorAktar, Fesih
dc.institutionauthorÖzekinci, Selver Özşener
dc.institutionauthorErdinç, Levent
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectRenal ischemia-reperfusion (IR)en_US
dc.subjectLow dose cyclosporin A (CsA)en_US
dc.subjectRenal perfusion pressureen_US
dc.subjectTNF-alphaen_US
dc.subjectCaspase-3en_US
dc.subjectRIP1en_US
dc.subjectRIP3en_US
dc.subjectMLKLen_US
dc.subjectCAMKIIen_US
dc.subjectCypDen_US
dc.titleInvolvement of necroptosıs and apoptosıs ın protectıve effects of cyclosporın a on ischemıa-reperfusıon injury in rat kıdneyen_US
dc.typeArticleen_US

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