Effect of airway dynamics on the development of larynx cancer

Basit Öğe Kaydı
dc.contributor.authorTaylan, Mahşuk
dc.contributor.authorCan, Ömer Faruk
dc.contributor.authorÇetinçakmak, Mehmet Güli
dc.contributor.authorÖzbay, Musa
dc.contributor.orcid0000-0003-4072-2270
dc.contributor.orcid0000-0003-0799-889X
dc.date.accessioned2024-04-24T15:59:28Z
dc.date.available2024-04-24T15:59:28Z
dc.date.issued2016
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractObjectives/HypothesisThis study aimed to investigate and measure airway dynamics in anatomical regions where laryngeal cancer was most common in comparison to other regions of the larynx, thereby determining the effect of airway dynamics on the development of laryngeal cancer. Study Design and MethodsPulmonary function test airflow data and larynx anatomy measurement data obtained by three-dimensional computed tomography. A healthy male adult was modeled by simulation using the ANSYS program. Analysis of air flow rates, pressure, and force were also made. ResultsThe supraglottic region average pressure was higher when compared to the subglottic region and clearly lower when compared to the glottic region. The subglottic had the lowest pressure and force levels. The glottic region was the first ranked location for laryngeal cancer; the supraglottic region was the second; and the frequency of laryngeal cancer was much lower in the subglottic region. Our data suggests that the high pressure and force contribute to an increased amount of contact and interaction between toxic particles and mucosa and to increased diffusion of the particles, leading to an increased carcinogenic effect and frequency of cancer. ConclusionLaryngeal cancer was found more frequently in regions with an increased pressure and force stress and reduced air velocity, with a subsequent increase in penetration of the inhaled toxic agents. These findings demonstrate the importance of basic physical fluid mechanics in cancer pathogenesis.en_US
dc.identifier.citationTaylan, M., Can, Ö. F., Çetinçakmak, M. G. ve Özbay, M. (2016). Effect of airway dynamics on the development of larynx cancer. Laryngoscope, 126(5), 1136-1142.
dc.identifier.doi10.1002/lary.25645
dc.identifier.endpage1142en_US
dc.identifier.issn0023-852X
dc.identifier.issn1531-4995
dc.identifier.issue5en_US
dc.identifier.pmid26372301
dc.identifier.scopus2-s2.0-84941710066
dc.identifier.scopusqualityQ1
dc.identifier.startpage1136en_US
dc.identifier.urihttps://doi.org/10.1002/lary.25645
dc.identifier.urihttps://hdl.handle.net/11468/14085
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/lary.25645
dc.identifier.volume126en_US
dc.identifier.wosWOS:000374769400029
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTaylan, Mahşuk
dc.institutionauthorCan, Ömer Faruk
dc.institutionauthorÇetinçakmak, Mehmet Güli
dc.institutionauthorÖzbay, Musa
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofLaryngoscope
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLarynx canceren_US
dc.subjectNumerical analysisen_US
dc.subjectAirway dynamicsen_US
dc.titleEffect of airway dynamics on the development of larynx canceren_US
dc.titleEffect of airway dynamics on the development of larynx cancer
dc.typeArticleen_US

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