Therapeutic effects of ellagic acid on L-arginin induced acute pancreatitis

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dc.contributor.authorYilmaz, Edip Erdal
dc.contributor.authorBozdag, Zubeyir
dc.contributor.authorIbiloglu, Ibrahim
dc.contributor.authorArikanoglu, Zulfu
dc.contributor.authorYazgan, Umit Can
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorGumus, Metehan
dc.date.accessioned2024-04-24T17:18:10Z
dc.date.available2024-04-24T17:18:10Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractPURPOSE: To investigate the therapeutic effects of ellagic acid on L-arginin induced acute pancreatitis in rats. METHODS: Thirty-two were split into four groups. Group 1 (control) rats were performed only laparotomy, no drugs were administered. Group 2 (control+EA) rats were administered 85mg/kg EA orally. Rats were sacrificed by cardiac puncture 24 hours after the administration. Group3 (AP) 24 hours after intraperitoneal L-arginine administration, rats were sacrificed by cardiac puncture. Group 4 (EA)-(AP): 85mg/kg EA was administered orally after the L-arginine administration. 24 hours later, rats were sacrificed by cardiac puncture. Serum TNF-alpha, IL-1 beta, IL-6, total oxidative status (TOS), total antioxidant capacity (TAC), amylase levels were determined in all groups. RESULTS: Group 3 (AP) rats showed significantly raised TOS level as compared to Group1 (control) rats (p<0.001). Following the EA therapy, a decrease in TOS was observed in Group 4 (AP+EA). TAC levels were significantly raised in the Group 4 (AP+EA) compared to the Group 3 (AP) (p=0.003). Group 3 (AP) showed significantly increased TNF-alpha, IL-1 beta and IL-6 serum levels as compared to Group 4 (AP+EA). Histopathological changes were supported our result. CONCLUSION: The healing effects of ellagic acid on inflammatory and oxidative stress were confirmed by histopathological and biochemical evaluations of the pancreatic tissue.en_US
dc.identifier.doi10.1590/S0102-865020160060000006
dc.identifier.endpage401en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue6en_US
dc.identifier.pmid27355747
dc.identifier.scopus2-s2.0-84976312613
dc.identifier.scopusqualityQ2
dc.identifier.startpage396en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-865020160060000006
dc.identifier.urihttps://hdl.handle.net/11468/18644
dc.identifier.volume31en_US
dc.identifier.wosWOS:000380361700006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEllagic Aciden_US
dc.subjectPancreatitisen_US
dc.subjectOxidative Stressen_US
dc.subjectRatsen_US
dc.titleTherapeutic effects of ellagic acid on L-arginin induced acute pancreatitisen_US
dc.titleTherapeutic effects of ellagic acid on L-arginin induced acute pancreatitis
dc.typeArticleen_US

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