Therapeutic effects of ellagic acid on L-arginin induced acute pancreatitis
dc.contributor.author | Yilmaz, Edip Erdal | |
dc.contributor.author | Bozdag, Zubeyir | |
dc.contributor.author | Ibiloglu, Ibrahim | |
dc.contributor.author | Arikanoglu, Zulfu | |
dc.contributor.author | Yazgan, Umit Can | |
dc.contributor.author | Kaplan, Ibrahim | |
dc.contributor.author | Gumus, Metehan | |
dc.date.accessioned | 2024-04-24T17:18:10Z | |
dc.date.available | 2024-04-24T17:18:10Z | |
dc.date.issued | 2016 | |
dc.department | Dicle Üniversitesi | en_US |
dc.description.abstract | PURPOSE: To investigate the therapeutic effects of ellagic acid on L-arginin induced acute pancreatitis in rats. METHODS: Thirty-two were split into four groups. Group 1 (control) rats were performed only laparotomy, no drugs were administered. Group 2 (control+EA) rats were administered 85mg/kg EA orally. Rats were sacrificed by cardiac puncture 24 hours after the administration. Group3 (AP) 24 hours after intraperitoneal L-arginine administration, rats were sacrificed by cardiac puncture. Group 4 (EA)-(AP): 85mg/kg EA was administered orally after the L-arginine administration. 24 hours later, rats were sacrificed by cardiac puncture. Serum TNF-alpha, IL-1 beta, IL-6, total oxidative status (TOS), total antioxidant capacity (TAC), amylase levels were determined in all groups. RESULTS: Group 3 (AP) rats showed significantly raised TOS level as compared to Group1 (control) rats (p<0.001). Following the EA therapy, a decrease in TOS was observed in Group 4 (AP+EA). TAC levels were significantly raised in the Group 4 (AP+EA) compared to the Group 3 (AP) (p=0.003). Group 3 (AP) showed significantly increased TNF-alpha, IL-1 beta and IL-6 serum levels as compared to Group 4 (AP+EA). Histopathological changes were supported our result. CONCLUSION: The healing effects of ellagic acid on inflammatory and oxidative stress were confirmed by histopathological and biochemical evaluations of the pancreatic tissue. | en_US |
dc.identifier.doi | 10.1590/S0102-865020160060000006 | |
dc.identifier.endpage | 401 | en_US |
dc.identifier.issn | 0102-8650 | |
dc.identifier.issn | 1678-2674 | |
dc.identifier.issue | 6 | en_US |
dc.identifier.pmid | 27355747 | |
dc.identifier.scopus | 2-s2.0-84976312613 | |
dc.identifier.scopusquality | Q2 | |
dc.identifier.startpage | 396 | en_US |
dc.identifier.uri | https://doi.org/10.1590/S0102-865020160060000006 | |
dc.identifier.uri | https://hdl.handle.net/11468/18644 | |
dc.identifier.volume | 31 | en_US |
dc.identifier.wos | WOS:000380361700006 | |
dc.identifier.wosquality | Q4 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | en_US |
dc.publisher | Acta Cirurgica Brasileira | en_US |
dc.relation.ispartof | Acta Cirurgica Brasileira | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Ellagic Acid | en_US |
dc.subject | Pancreatitis | en_US |
dc.subject | Oxidative Stress | en_US |
dc.subject | Rats | en_US |
dc.title | Therapeutic effects of ellagic acid on L-arginin induced acute pancreatitis | en_US |
dc.title | Therapeutic effects of ellagic acid on L-arginin induced acute pancreatitis | |
dc.type | Article | en_US |