Phytochemical analysis and biological evaluation of hypericum linarioides bosse: in vitro and in silico studies

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dc.contributor.authorAltay, Ahmet
dc.contributor.authorYeniçeri, Esma Kübra Kağan
dc.contributor.authorTaslimi, Parham
dc.contributor.authorTok, Tuğba Taşkın
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorKöksar, Ekrem
dc.date.accessioned2024-04-24T15:59:33Z
dc.date.available2024-04-24T15:59:33Z
dc.date.issued2022
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study is to determine the phenolic composition of Hypericum linarioides Bosse, to assess its various biological properties, and finally to confirm the experimental data of enzyme inhibitions via docking studies. LC-MS/MS analysis performed over methanol extract (ME) revealed the presence of 27 phytochemicals. Antioxidant activity results indicated that ME had the strongest DPPH radical scavenging and ferric ion reducing capacity than water and hexane extracts. XTT assays revealed the strongest anti-proliferative activity of ME against MCF-7 and HT-29 cancer cells. Flow cytometry results also confirmed the notable apoptotic effect of ME on MCF-7 cells through mitochondria-dependent pathway. Enzyme activity results exhibited the most promising acetylcholinesterase and alpha-glycosidase inhibitory activities of the ME. Molecular docking calculations of alpha-glycosidase with the major compounds (1, 15, 17 and 19) indicated that 17 (isoquercitrin) had the best docking binding energy (-10.92 kcal/mol) with appropriate binding interactions.en_US
dc.description.sponsorshipThis work was financially supported by grants from Erzincan University Scientific Research Projects Coordination Commission (EU-BAP) (Project No: 2020-736). The authors thank Esin Ak Yalcin and the research group for technical assistance. The authors also thank Prof. Dr. Ali Kandemir for plant identification.en_US
dc.description.sponsorshipErzincan Binali Yildirim University 2020-736
dc.identifier.citationThis work was financially supported by grants from Erzincan University Scientific Research Projects Coordination Commission (EU-BAP) (Project No: 2020-736). The authors thank Esin Ak Yalcin and the research group for technical assistance. The authors also thank Prof. Dr. Ali Kandemir for plant identification.
dc.identifier.doi10.1002/slct.202200039
dc.identifier.issn2365-6549
dc.identifier.issue23en_US
dc.identifier.scopus2-s2.0-85132792746
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202200039
dc.identifier.urihttps://hdl.handle.net/11468/14134
dc.identifier.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202200039
dc.identifier.volume7en_US
dc.identifier.wosWOS:000810719700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYilmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiological activityen_US
dc.subjectFlow cytometryen_US
dc.subjectHypericum linarioides bosseen_US
dc.subjectLc-Msen_US
dc.subjectMsen_US
dc.subjectMolecular dockingen_US
dc.titlePhytochemical analysis and biological evaluation of hypericum linarioides bosse: in vitro and in silico studiesen_US
dc.titlePhytochemical analysis and biological evaluation of hypericum linarioides bosse: in vitro and in silico studies
dc.typeArticleen_US

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