The Clinical Findings and Prophylactic Treatment in Children with Factor X Deficiency

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dc.contributor.authorKarabel, Musemma
dc.contributor.authorSoker, Murat
dc.contributor.authorYildirim, Aysen Turedi
dc.contributor.authorOymak, Yesim
dc.contributor.authorKelekci, Selvi
dc.contributor.authorKarabel, Duran
dc.date.accessioned2024-04-24T17:20:28Z
dc.date.available2024-04-24T17:20:28Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractFactor X (FX) is the component of both extrinsic and intrinsic coagulation cascade and is the first enzyme of the common pathway which results in thrombus. Congenital FX deficiency (FXD) is an extremely rare coagulation defect. In this study, we aimed to investigate the clinical and laboratory data of the patients diagnosed with FXD. The files of the 15 patients (7 female, 8 male) diagnosed and followed up for FXD within the last 4 years were evaluated retrospectively. The mean age of the patients was 29 months (min-max: 1-144 months). The most presenting complaints were easy bruisability (n=8; 53%) and epistaxis (n=8; 53%). FX levels were <1% in six patients, 1-5% in four patients, and >5% in five patients. Heparin added-Protrombin Complex was used for prophlaxy (n=11; 73%). Any treatment-related complication was not observed. Heparin-added PCC can be used safely for effective prophlaxy. We suggest that family history is important when considering prophlaxy and in patients with life-threatening bleeding or with FXD sibling the prophlaxy should be introduced in the early course.en_US
dc.identifier.doi10.3109/08880018.2013.782380
dc.identifier.endpage722en_US
dc.identifier.issn0888-0018
dc.identifier.issn1521-0669
dc.identifier.issue8en_US
dc.identifier.pmid23560890
dc.identifier.scopus2-s2.0-84885934062
dc.identifier.scopusqualityQ2
dc.identifier.startpage717en_US
dc.identifier.urihttps://doi.org/10.3109/08880018.2013.782380
dc.identifier.urihttps://hdl.handle.net/11468/19075
dc.identifier.volume30en_US
dc.identifier.wosWOS:000326716700005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofPediatric Hematology and Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoagulationen_US
dc.subjectHemostasis-Thrombosisen_US
dc.subjectPediatricsen_US
dc.titleThe Clinical Findings and Prophylactic Treatment in Children with Factor X Deficiencyen_US
dc.titleThe Clinical Findings and Prophylactic Treatment in Children with Factor X Deficiency
dc.typeArticleen_US

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