Evaluation of the relationship between splenic iron overload and liver, heart and muscle features evident on T2?-weighted magnetic resonance imaging

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dc.authorid0000-0003-4781-9729en_US
dc.authorid0000-0001-8463-2723en_US
dc.authorid0000-0001-5137-0501en_US
dc.authorid0000-0003-4792-8722en_US
dc.contributor.authorÇetinçakmak, Mehmet Güli
dc.contributor.authorHattapoǧlu, Salih
dc.contributor.authorSöker, Murat
dc.contributor.authorEkici, Faysal
dc.contributor.authorYılmaz, Kamil
dc.contributor.authorGöya, Cemil
dc.contributor.authorHamidi, Cihad
dc.date.accessioned2021-07-12T13:13:52Z
dc.date.available2021-07-12T13:13:52Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalıen_US
dc.descriptionWOS:000532343200008
dc.descriptionPMID: 32369274
dc.description.abstractBackground. Splenic iron overload is the most common clinical condition in patients with thalassemia. However, few studies of the effects of splenectomy have been published. Objectives. To evaluate the relationship between splenic iron overload and liver, heart and muscle features visible in T2∗-weighted magnetic resonance imaging, and to investigate the effects of splenectomy on these tissues in patients with beta-thalassemia major (TM). Material and methods. We retrospectively included 131 patients (76 male and 55 female) diagnosed with TM. All radiological assessments were performed with the aid of a Philips Achieva 1.5T scanner running a multiecho gradient-echo sequence. Hepatic and splenic T2∗ values were assessed in the same gradient multiecho series. Muscle T2∗ values were assessed in the shoulder girdle muscles adjacent to the heart area. The relationships among splenic T2∗, hepatic T2∗, cardiac T2∗ and muscle T2∗ parameters, serum ferritin levels, age and other parameters were evaluated. Results. The splenic T2∗ value correlated with serum ferritin level and the hepatic T2∗ value (p < 0.001 and p < 0.001, respectively). The splenic T2∗ value did not correlate with age, cardiac or muscle T2∗ values, or with spleen size (p = 0.27, 0.21, 0.99, and 0.39, respectively). The muscle T2∗ value correlated weakly with the serum ferritin level (p = 0.022). The cardiac T2∗ value was lower and the liver size greater in patients who had undergone splenectomy compared with those who had not (p < 0.001 and 0.001, respectively). Conclusions. Splenic iron overload correlated with hepatic overload and the serum ferritin level. Splenectomy increased cardiac iron overload and triggered liver enlargement. However, the muscle iron overload was low and the muscles were therefore unaffected by splenectomy.en_US
dc.identifier.citationÇetinçakmak, M. G., Hattapoǧlu, S., Söker, M., Ekici, F., Yılmaz, K., Göya, C. ve diğerleri. (2020). Evaluation of the relationship between splenic iron overload and liver, heart and muscle features evident on T2∗-weighted magnetic resonance imaging. Advances in Clinical and Experimental Medicine, 29(4), 475-480.en_US
dc.identifier.doi10.17219/acem/116758
dc.identifier.endpage480en_US
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue4en_US
dc.identifier.pmid32369274
dc.identifier.scopus2-s2.0-85084693814
dc.identifier.scopusqualityQ1
dc.identifier.startpage475en_US
dc.identifier.urihttps://www.advances.umed.wroc.pl/pdf/2020/29/4/475.pdf
dc.identifier.urihttps://hdl.handle.net/11468/7227
dc.identifier.volume29en_US
dc.identifier.wosWOS:000532343200008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇetinçakmak, Mehmet Güli
dc.institutionauthorHattapoǧlu, Salih
dc.institutionauthorSöker, Murat
dc.institutionauthorEkici, Faysal
dc.institutionauthorYılmaz, Kamil
dc.institutionauthorGöya, Cemil
dc.institutionauthorHamidi, Cihad
dc.language.isoenen_US
dc.publisherWroclaw University of Medicineen_US
dc.relation.ispartofAdvances in Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIron overloaden_US
dc.subjectMR imagingen_US
dc.subjectSpleenen_US
dc.subjectThalassemiaen_US
dc.titleEvaluation of the relationship between splenic iron overload and liver, heart and muscle features evident on T2?-weighted magnetic resonance imagingen_US
dc.titleEvaluation of the relationship between splenic iron overload and liver, heart and muscle features evident on T2?-weighted magnetic resonance imaging
dc.typeArticleen_US

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