Enhancing aseptic inflammation resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate: A novel β-Cyclodextrin complex as a therapeutic agent

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dc.authorid0000-0002-4129-6931en_US
dc.authorid0000-0001-8884-5646en_US
dc.authorid0000-0001-6087-6643en_US
dc.authorid0000-0003-0079-4755en_US
dc.authorid0000-0002-4238-5012en_US
dc.contributor.authorZhumakova, Symbat
dc.contributor.authorTokusheva, Aliya
dc.contributor.authorZharkynbek, Tolganay
dc.contributor.authorBalabekova, Marina
dc.contributor.authorKõks, Sulev
dc.contributor.authorSeilkhanov, Tulegen
dc.contributor.authorDembitsky, Valery
dc.contributor.authorAydemir, Murat
dc.date.accessioned2025-02-17T07:54:11Z
dc.date.available2025-02-17T07:54:11Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.description.abstractThe synthesized compound, 1-(2-ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate (EPPP), and its 1:1 complex with β-cyclodextrin (EPPPβCD) have been characterized for the first time through a comprehensive suite of analytical methods. This study explores the therapeutic potential of EPPPβCD in modulating immune responses and accelerating the resolution of septic inflammation induced by chromium and vanadium ions in outbred male rats. The research highlights the significant impact of EPPPβCD on the dynamics of regulatory T lymphocytes (Tregs), notably causing a reduction in the CD4+CD25+ fractions at the onset of inflammation. This effect is attributed to the inhibition of Treg proliferation, which is crucial in hastening the resolution of inflammation. These findings underscore the potential of EPPPβCD as a promising therapeutic agent in controlling and mitigating inflammation mediated by heavy metal exposure, thereby offering a new avenue for the development of anti-inflammatory treatments.en_US
dc.identifier.citationZhumakova, S., Tokusheva, Al., Zharkynbek, T., Balabekova, M., Koks, S., Seilkhanov, T. ve diğerleri. (2024). Enhancing aseptic inflammation resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate: A novel β-Cyclodextrin complex as a therapeutic agent. Molecules, 29(21), 1-12.en_US
dc.identifier.endpage12en_US
dc.identifier.issn1420-3049
dc.identifier.issue21en_US
dc.identifier.pmid39519778
dc.identifier.scopus2-s2.0-85208587248
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/11468/29462
dc.identifier.volume29en_US
dc.identifier.wosWOS:001352509500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.institutionauthorAydemir, Murat
dc.language.isoenen_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.ispartofMolecules
dc.relation.isversionof10.3390/molecules29215135en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1-(2-ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate (EPPP)en_US
dc.subjectAmmonium vanadate (NH4VO3)en_US
dc.subjectAseptic inflammationen_US
dc.subjectComplex EPPP with β-cyclodextrin (EPPPβCD)en_US
dc.subjectHeavy metal technology-related exposureen_US
dc.subjectPotassium bichromate (K2Cr2O7); supracomplexen_US
dc.titleEnhancing aseptic inflammation resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate: A novel β-Cyclodextrin complex as a therapeutic agenten_US
dc.titleEnhancing aseptic inflammation resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate: A novel ?-Cyclodextrin complex as a therapeutic agent
dc.typeArticleen_US

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