Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study

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dc.contributor.authorYilmaz, Ahmet
dc.contributor.authorElbey, Bilal
dc.contributor.authorYazgan, Umit Can
dc.contributor.authorDonder, Ahmet
dc.contributor.authorArslan, Necmi
dc.contributor.authorArslan, Serkan
dc.contributor.authorAlabalik, Ulag
dc.date.accessioned2024-04-24T17:12:15Z
dc.date.available2024-04-24T17:12:15Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground. The aim of the study was to analyse the effect of caffeic acid phenethyl ester (CAPE) on fluoxetine-induced hepatotoxicity in rats. Materials and Methods. Group I served as control. Group II received CAPE intraperitoneally. Group III received fluoxetine per orally. Group IV received fluoxetine and CAPE. The total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), and liver enzymes including paraoxonase-1 (PON-1), aspartate transaminase, and alanine transaminase levels were measured. Liver tissues were processed histopathologically for evaluation of liver injury and to validate the serum enzyme levels. Results. An increase in TOS and OSI and a decrease in TAC and PON-1 levels in serum and liver tissues of Group III were observed compared to Groups I and II. After treatment with CAPE, the level of TOS and OSI decreased while TAC and PON-1 increased in serum and liver in Group IV. Histopathological examination of the liver revealed hepatic injury after fluoxetine treatment and reduction of injury with CAPE treatment. Conclusion. Our results suggested that CAPE treatment provided protection against fluoxetine toxicity. Following CAPE treatment with fluoxetine-induced hepatotoxicity, TOS and OSI levels decreased, whereas PON-1 and TAC increased in the serum and liver.en_US
dc.description.sponsorshipDicle University Scientific Research Projects Directorate (DUBAP), Diyarbakir, Turkey [14 TF-51]en_US
dc.description.sponsorshipThis study was supported by the Dicle University Scientific Research Projects Directorate (DUBAP, Project no. 14 TF-51), Diyarbakir, Turkey.en_US
dc.identifier.doi10.1155/2016/1247191
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.pmid27144157
dc.identifier.scopus2-s2.0-84966430560
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/2016/1247191
dc.identifier.urihttps://hdl.handle.net/11468/17909
dc.identifier.volume2016en_US
dc.identifier.wosWOS:000374936600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofBiomed Research International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleProtective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Studyen_US
dc.titleProtective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study
dc.typeArticleen_US

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