Evaluation of New Biomarkers in the Prediction of Malignant Mesothelioma in Subjects with Environmental Asbestos Exposure

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dc.contributor.authorDemir, Melike
dc.contributor.authorKaya, Halide
dc.contributor.authorTaylan, Mahsuk
dc.contributor.authorEkinci, Aysun
dc.contributor.authorYilmaz, Sureyya
dc.contributor.authorTeke, Fatma
dc.contributor.authorSezgi, Cengizhan
dc.date.accessioned2024-04-24T16:01:53Z
dc.date.available2024-04-24T16:01:53Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe purpose of this study was to investigate the potential value of certain biomarkers in predicting the presence of malignant pleural mesothelioma (MPM) in individuals environmentally exposed to asbestos. This prospective study investigated three groups; a control group composed of 41 healthy subjects, an asbestos exposure group consisting of 48 individuals, and a MPM group consisting of 42 patients. Serum levels of soluble mesothelin-related peptide (SMRP), thioredoxin-1 (TRX), epidermal growth factor receptor (EGFR), fibulin-3, syndecan-1 (SDC-1), and mesothelin were determined. Benign pleural plaques were present in 27 (58.3 %) of the individuals in the asbestos exposure group. The asbestos exposure group had significantly higher mean TRX, SMRP, and mesothelin levels compared to the control group (p = 0.023, p = 0.011, and p < 0.001, respectively). Compared to the asbestos exposure group, the MPM group had significantly higher mean EGFR, TRX, SMRP, and fibulin-3 levels (p = 0.041, p = 0.023, p = 0.002, and p = 0.001, respectively), and significantly lower mean SDC-1 levels (p = 0.002). Unlike the other biomarkers, SMRP and TRX levels increased in a graded fashion among the control, asbestos exposure, and MPM groups, respectively. Area under the curve values for SMRP and TRX were 0.86 and 0.72, respectively (95 % CI 0.79-0.92 and p < 0.001 for SMRP, and 95 % CI 0.62-0.81 and p < 0.001 for TRX). The cut-off value for SMRP was 0.62 nmol/l (sensitivity: 97.6 %, specificity: 68.9 %, positive predictive value (PPV): 56.2 %, and negative predictive value (NPV): 98.3 %) and for TRX was 156.67 ng/ml (sensitivity: 92.9 %, specificity: 77.6 %, PPV: 41.4 %, and NPV: 92.1 %). The combination of the biomarkers reached a sensitivity of 100 %, but had lower specificity (as high as 27.7 %). Serum biomarkers may be helpful for early diagnosis of MPM in asbestos-exposed cases. SMRP and TRX increased in a graded fashion from the controls to asbestos exposure and MPM groups. These two seem to be the most valuable biomarkers for the diagnosis of MPM, both individually and in combination.en_US
dc.description.sponsorshipDicle University Scientific Project Unit (DUBAP) [14-TF-48]en_US
dc.description.sponsorshipThe study was supported by Dicle University Scientific Project Unit (DUBAP). Project number was 14-TF-48.en_US
dc.identifier.doi10.1007/s00408-016-9868-1
dc.identifier.endpage417en_US
dc.identifier.issn0341-2040
dc.identifier.issn1432-1750
dc.identifier.issue3en_US
dc.identifier.pmid27032653
dc.identifier.scopus2-s2.0-84962164172
dc.identifier.scopusqualityQ1
dc.identifier.startpage409en_US
dc.identifier.urihttps://doi.org/10.1007/s00408-016-9868-1
dc.identifier.urihttps://hdl.handle.net/11468/14456
dc.identifier.volume194en_US
dc.identifier.wosWOS:000376261300010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofLung
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMalignant Pleural Mesotheliomaen_US
dc.subjectAsbestosen_US
dc.subjectBiomarkersen_US
dc.subjectSoluble Mesothelin-Related Peptideen_US
dc.subjectThioredoxin-1en_US
dc.titleEvaluation of New Biomarkers in the Prediction of Malignant Mesothelioma in Subjects with Environmental Asbestos Exposureen_US
dc.titleEvaluation of New Biomarkers in the Prediction of Malignant Mesothelioma in Subjects with Environmental Asbestos Exposure
dc.typeArticleen_US

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