The evaluation of effects of demographic features, biochemical parameters, and cytokines on clinical outcomes in patients with acute renal failure

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dc.contributor.authorKadiroglu, Ali Kemal
dc.contributor.authorSit, Dede
dc.contributor.authorAtay, A. Engin
dc.contributor.authorKayabasi, Hasan
dc.contributor.authorAltintas, Abdullah
dc.contributor.authorYilmaz, M. Emin
dc.date.accessioned2024-04-24T16:24:38Z
dc.date.available2024-04-24T16:24:38Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim. To evaluate the effects of cytokines, biochemical parameters and demographic features on clinical outcomes of acute renal failure (ARF). Patients and Methods. 59 patients with acute renal failure (28 men, 31 women) were enrolled to the study. Cytokines, biochemical parameters, and complete blood count were measured. Patients were divided into two groups: as survivors (group 1, n = 46) and nonsurvivors (group 2, n = 13). Results. Mean age of patients were 52.3 +/- 17.9 years. 46 patients survived (77.9%) and 13 patients died (22. 1 %). There was a statistically significant relationship between IL-2R, IL-6, and TNF-oc levels and mortality rates (p = 0.004, p = 0.016, p = 0.020, respectively) and between TC levels and mortality rates (p = 0.041). In multivariable logistic regression analysis, the effects of proinflammatory cytokines (IL- I beta, IL-2R, IL-6, TNF alpha, CRP, and ESR) on the clinical outcomes in ARF was observed to be statistically significant (r = 0.341, p = 0.005). Conclusion. We realized that in totally demographic features (male gender, advanced age, poor nutritional status), biochemical parameters (TC, albumin, and hemoglobin) and cytokine levels (IL-2R, IL-6, TNF-oc), CRP and ESR may be predictive factors for mortality in patients with ARF.en_US
dc.identifier.doi10.1080/08860220701274991
dc.identifier.endpage508en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue4en_US
dc.identifier.pmid17497476
dc.identifier.scopus2-s2.0-34248584952
dc.identifier.scopusqualityQ2
dc.identifier.startpage503en_US
dc.identifier.urihttps://doi.org/10.1080/08860220701274991
dc.identifier.urihttps://hdl.handle.net/11468/16799
dc.identifier.volume29en_US
dc.identifier.wosWOS:000246966300018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrpen_US
dc.subjectCytokinesen_US
dc.subjectAcute Renal Failureen_US
dc.subjectClinical Outcomesen_US
dc.titleThe evaluation of effects of demographic features, biochemical parameters, and cytokines on clinical outcomes in patients with acute renal failureen_US
dc.titleThe evaluation of effects of demographic features, biochemical parameters, and cytokines on clinical outcomes in patients with acute renal failure
dc.typeArticleen_US

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