A Clinical, Radiographic and Laboratory Evaluation of Prognostic Factors in 363 Patients with Malignant Pleural Mesothelioma

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dc.contributor.authorTanrikulu, Abdullah Cetin
dc.contributor.authorAbakay, Abdurrahman
dc.contributor.authorKaplan, Mehmet Ali
dc.contributor.authorKucukoner, Mehmet
dc.contributor.authorPalanci, Yilmaz
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorSezgi, Cengizhan
dc.date.accessioned2024-04-24T17:14:27Z
dc.date.available2024-04-24T17:14:27Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Malignant pleural mesothelioma (MPM) has a poor prognosis. Objectives: Only few studies in literature investigated the presence of pleural fluid and radiographic findings for the prognosis of MPM. Methods: We retrospectively investigated the hospital charts of 363 MPM patients who were diagnosed from January 1989 to March 2010. Survival time was calculated by the Kaplan-Meier method. Pretreatment clinical, laboratory and radiographic features of each patient at the time of diagnosis were obtained from patients' charts. Results: The mean age of 363 patients (217 men, 146 women) was 50.6 +/- 11.2 years (range 19-85) and the mean survival time was 11.7 +/- 8.6 months (range 1-53). Histological types of MPM were epithelial (71.2%), mixed (15.9%) and sarcomatous type (4.9%). The frequency of disease stages were 31.4% for stage 1, 24.2% for stage 2, 28.6% for stage 3 and 15.8% for stage 4. The most frequent symptoms were dyspnea (82.1%), chest pain (68.3%) and weight loss (58.9%). Results of univariate and multivariate analyses revealed that a Karnofsky performance score <= 60, a pleural fluid glucose level <= 40 mg/dl, a C-reactive protein level > 50 mg/l, a serum lactate dehydrogenase level > 500 U/l, the presence of pleural fluid, pleural thickening > 1 cm and a platelet count of > 420 x 10(3)/mu l were found to be associated with poor prognosis in MPM. Conclusions: Our data suggest that low pleural fluid glucose and high C-reactive protein, the presence of pleural fluid and pleural thickening were associated with poor MPM prognosis. Further prospective studies are needed to highlight prognostic factors more clearly. Copyright (C) 2010 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000321370
dc.identifier.endpage487en_US
dc.identifier.issn0025-7931
dc.identifier.issue6en_US
dc.identifier.pmid20881372
dc.identifier.scopus2-s2.0-78649327372
dc.identifier.scopusqualityQ1
dc.identifier.startpage480en_US
dc.identifier.urihttps://doi.org/10.1159/000321370
dc.identifier.urihttps://hdl.handle.net/11468/17962
dc.identifier.volume80en_US
dc.identifier.wosWOS:000288206400007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofRespiration
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAsbestos Exposureen_US
dc.subjectMalignant Pleural Mesotheliomaen_US
dc.subjectC-Reactive Proteinen_US
dc.titleA Clinical, Radiographic and Laboratory Evaluation of Prognostic Factors in 363 Patients with Malignant Pleural Mesotheliomaen_US
dc.titleA Clinical, Radiographic and Laboratory Evaluation of Prognostic Factors in 363 Patients with Malignant Pleural Mesothelioma
dc.typeArticleen_US

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