Massive Metformin Overdose in Two Subjects with Suicidal Behavior: Brief Communication

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dc.contributor.authorArikan, Senay
dc.contributor.authorTuzcu, Alpaslan
dc.contributor.authorBahceci, Mithat
dc.contributor.authorKaplan, Mehmet Ali
dc.contributor.authorGokalp, Deniz
dc.date.accessioned2024-04-24T17:27:36Z
dc.date.available2024-04-24T17:27:36Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractLactic acidosis is a well-recognized side effect of metformin, especially in patients with renal failure. Only a few cases of deliberate self-poisoning with metformin have been described in the literature. The mechanism of metformin-associated lactic acidosis is complex. In the absence of acute overdose, metformin-associated lactic acidosis rarely develops in patients without comorbidities such as renal or hepatic insufficiency or acute infection. We report two patients who had a large dose of metformin in an attempt to harm themselves and presented with lactic acidosis. In our experience, metformin intoxication may lead a high anion gap metabolic acidosis after a suicide attempt. Sodium bicarbonate infusion is able to correct the acid-base metabolism sufficiently in subjects with normal renal functions.en_US
dc.identifier.doi10.5336/medsci.2010-19297
dc.identifier.endpage562en_US
dc.identifier.issn1300-0292
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84855943601en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage559en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2010-19297
dc.identifier.urihttps://hdl.handle.net/11468/20082
dc.identifier.volume32en_US
dc.identifier.wosWOS:000305320400042
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOverdoseen_US
dc.subjectAcidosisen_US
dc.subjectLacticen_US
dc.subjectMetforminen_US
dc.subjectBicarbonatesen_US
dc.titleMassive Metformin Overdose in Two Subjects with Suicidal Behavior: Brief Communicationen_US
dc.typeArticleen_US

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