Massive Metformin Overdose in Two Subjects with Suicidal Behavior: Brief Communication
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Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ortadogu Ad Pres & Publ Co
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Lactic acidosis is a well-recognized side effect of metformin, especially in patients with renal failure. Only a few cases of deliberate self-poisoning with metformin have been described in the literature. The mechanism of metformin-associated lactic acidosis is complex. In the absence of acute overdose, metformin-associated lactic acidosis rarely develops in patients without comorbidities such as renal or hepatic insufficiency or acute infection. We report two patients who had a large dose of metformin in an attempt to harm themselves and presented with lactic acidosis. In our experience, metformin intoxication may lead a high anion gap metabolic acidosis after a suicide attempt. Sodium bicarbonate infusion is able to correct the acid-base metabolism sufficiently in subjects with normal renal functions.
Açıklama
Anahtar Kelimeler
Overdose, Acidosis, Lactic, Metformin, Bicarbonates
Kaynak
Turkiye Klinikleri Tip Bilimleri Dergisi
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
32
Sayı
2
