Association of subclinical hypothyroidism with dyslipidemia and increased carotid intima-media thickness in children

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dc.authorid0000-0002-5299-9480en_US
dc.authorid0000-0002-9809-0977en_US
dc.authorid0000-0003-0985-4259en_US
dc.authorid0000-0003-1587-9559en_US
dc.authorid0000-0001-1456-5625en_US
dc.contributor.authorÜnal, Edip
dc.contributor.authorAkın, Alper
dc.contributor.authorYıldırım, Ruken
dc.contributor.authorDemir, Vasfiye
dc.contributor.authorYıldız, İsmail
dc.contributor.authorHaspolat, Yusuf Kenan
dc.date.accessioned2021-12-01T06:32:12Z
dc.date.available2021-12-01T06:32:12Z
dc.date.issued2017en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractObjective: Subclinical hypothyroidism (SH) is defined as an elevated serum thyroid-stimulating hormone (TSH) level with free thyroxine (fT4) level in the normal range. There are very few studies in the literature reporting on the effect of SH on lipid metabolism and carotid intima-media thickness (CIMT) in children. Methods: The study included 38 children diagnosed with SH and a control group comprising 38 healthy, euthyroid children. SH was diagnosed based on an elevated TSH level (4.2-20 mIU/L) and normal fT4 level measured in two morning fasting blood samples obtained at an interval of 2 to 6 weeks. Blood samples were collected by venipuncture in the morning after an overnight fast. Results: The patient group included 38 children (16 male, 22 female) with SH and the control group -38 healthy, euthyroid children (20 male, 18 female). Mean age was 8.1±3.6 (range, 3.5-15) years in the patient group and 8.9±2.4 (range, 4.5-15) years in the control group. In the patient group, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C), and LDL-C/HDL-C were higher compared to the control group (p=0.049, p=0.014, p=0.002, and 0.003, respectively). In the patient group, CIMT was also significantly higher compared to the control group (p=0.001). The patient group was further divided into two subgroups based on their serum TSH level: (I) patients with mildly elevated TSH (TSH=4.2±10 mIU/L) (n=33) and (II) patients with high TSH (TSH≥10 mIU/L) (n=5). However, no significant difference was found between the patients with mild and severe SH with regard to TC, LDL-C, HDL-C, triglyceride level and CIMT levels (p=0.635, p=0.424, p=0.310, p=0.342, and 0.610, respectively). Conclusion: Subclinical hypothyroidism leads to increased dyslipidemia (increased TC and LDL) and increased CIMT, which leads to increased risk of cardiovascular disease. Further studies are needed to substantiate these findings in children with SH.en_US
dc.identifier.citationÜnal, E., Akın, A., Yıldırım, R., Demir, V., Yıldız, İ., Haspolat, Y. K. ve diğerleri. (2017). Association of subclinical hypothyroidism with dyslipidemia and increased carotid intima-media thickness in children. Journal of Clinical Research in Pediatric Endocrinology, 9(2), 144-149.en_US
dc.identifier.doi10.4274/jcrpe.3719
dc.identifier.endpage149en_US
dc.identifier.issue2en_US
dc.identifier.pmid28008862
dc.identifier.scopus2-s2.0-85020162922
dc.identifier.scopusqualityN/A
dc.identifier.startpage144en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/28008862/
dc.identifier.urihttps://hdl.handle.net/11468/8347
dc.identifier.volume9en_US
dc.identifier.wosWOS:000406446700009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÜnal, Edip
dc.institutionauthorAkın, Alper
dc.institutionauthorYıldırım, Ruken
dc.institutionauthorDemir, Vasfiye
dc.institutionauthorYıldız, İsmail
dc.institutionauthorHaspolat, Yusuf Kenan
dc.language.isoenen_US
dc.publisherGalenos Yayınevien_US
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSubclinical hypothyroidismen_US
dc.subjectCarotid intima-media thicknessen_US
dc.subjectDyslipidemia childhooden_US
dc.titleAssociation of subclinical hypothyroidism with dyslipidemia and increased carotid intima-media thickness in childrenen_US
dc.titleAssociation of subclinical hypothyroidism with dyslipidemia and increased carotid intima-media thickness in children
dc.typeArticleen_US

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