The antioxidant effects of pomegranate extract on local and remote organs in a mesenteric ischemia and reperfusion model

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dc.contributor.authorKilic, Elif
dc.contributor.authorTurkoglu, Ahmet
dc.contributor.authorKeles, Aysenur
dc.contributor.authorEkinci, Aysun
dc.contributor.authorKesgin, Siddika
dc.contributor.authorGumus, Metehan
dc.date.accessioned2024-04-24T17:14:47Z
dc.date.available2024-04-24T17:14:47Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: We investigated whether pomegranate extract plays a protective antioxidant role against mesenteric ischemia-reperfusion injury (IR), which can lead to a systemic response and damage distant organs, such as the lung, liver, and kidney. Methods: Forty female Wistar-Albino rats were separated into four groups: laparotomy, laparotomy + PG, mesenteric IR, and mesenteric IR and pomegranate (IR + PG). In the laparotomy + PG and IR + PG groups, pomegranate (225 mg/kg) was given by oral gavage at the beginning of the study. Ischemia was induced for 30 minutes, and reperfusion was subsequently allowed for 60 minutes in the IR and IR + PG groups. The malondialdehyde (MDA) and total antioxidant activity (AOA) levels were evaluated in blood samples. Additionally, all tissues were removed for the measurement of AOA and total oxidant status as well as for subsequent histopathological evaluation. The oxidative stress index was calculated. Results: Histopathological changes in all organs were significantly higher in the IR group and significantly lower in the IR + PG group vs. the other groups. Serum MDA levels were significantly lower in the IR + PG group than in the IR group. No significant difference was found in AOA levels of the groups. Discussion: These data may explain the positive protective effects of pomegranate based on the histopathologic findings in ischemic conditions in an intestinal IR injury model.en_US
dc.identifier.doi10.1179/1351000215Y.0000000013
dc.identifier.endpage13en_US
dc.identifier.issn1351-0002
dc.identifier.issn1743-2928
dc.identifier.issue1en_US
dc.identifier.pmid26010809
dc.identifier.scopus2-s2.0-84978763884
dc.identifier.scopusqualityQ2
dc.identifier.startpage6en_US
dc.identifier.urihttps://doi.org/10.1179/1351000215Y.0000000013
dc.identifier.urihttps://hdl.handle.net/11468/18190
dc.identifier.volume21en_US
dc.identifier.wosWOS:000373311900002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRedox Report
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPomegranateen_US
dc.subjectIntestinal Ischemiaen_US
dc.subjectReperfusionen_US
dc.subjectMalondialdehydeen_US
dc.subjectTotal Antioxidant Activityen_US
dc.subjectTotal Oxidant Statusen_US
dc.titleThe antioxidant effects of pomegranate extract on local and remote organs in a mesenteric ischemia and reperfusion modelen_US
dc.titleThe antioxidant effects of pomegranate extract on local and remote organs in a mesenteric ischemia and reperfusion model
dc.typeArticleen_US

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