The importance of paraoxonase 1 activity, nitric oxide and lipid peroxidation in hepatosteatosis

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dc.contributor.authorAtamer, A.
dc.contributor.authorBilici, A.
dc.contributor.authorYenice, N.
dc.contributor.authorSelek, S.
dc.contributor.authorIlhan, N.
dc.contributor.authorAtamer, Y.
dc.date.accessioned2024-04-24T17:14:43Z
dc.date.available2024-04-24T17:14:43Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study evaluated the changes in oxidative status in hepatosteatosis patients in terms of lipid peroxidation, nitric oxide (NO) and paraoxonase I (PON1) activity. A total of 49 patients with hepatosteatosis (29 males and 20 females, mean age 47.2 +/- 3.6 years) and 25 healthy subjects (IS males and 10 females, mean age 46.1 +/- 3.2 years) were enrolled in the study. Serum PON1 was measured spectrophotometrically, malondialdehyde (MDA), an end-product of lipid peroxidation, was determined using the thiobarbituric acid method., and NO was assessed using the Griess reaction. Lipid and other biochemical parameters were determined by routine laboratory methods. PON1 activity and NO levels were significantly decreased and MDA levels significantly increased in hepatosteatosis patients compared with healthy subjects. PON1 activity was correlated with MDA level and NO level. In conclusion, oxidative stress seems significantly to suppress PON1 synthesis in hepatosteatosis patients. In addition, oxidative stress and oxidant-antioxidant imbalance may be part of the cytotoxic mechanisms leading to liver cell injury.en_US
dc.identifier.doi10.1177/147323000803600419
dc.identifier.endpage776en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue4en_US
dc.identifier.pmid18652773
dc.identifier.scopus2-s2.0-52049099870
dc.identifier.scopusqualityQ2
dc.identifier.startpage771en_US
dc.identifier.urihttps://doi.org/10.1177/147323000803600419
dc.identifier.urihttps://hdl.handle.net/11468/18154
dc.identifier.volume36en_US
dc.identifier.wosWOS:000258349100019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of International Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatosteatosisen_US
dc.subjectParaoxonaseen_US
dc.subjectNitric Aciden_US
dc.subjectLipid Peroxidationen_US
dc.subjectLipoproteinen_US
dc.titleThe importance of paraoxonase 1 activity, nitric oxide and lipid peroxidation in hepatosteatosisen_US
dc.titleThe importance of paraoxonase 1 activity, nitric oxide and lipid peroxidation in hepatosteatosis
dc.typeArticleen_US

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