The effects of Mannheimia haemolytica and albendazole on marbofloxacin pharmacokinetics in lambs
dc.contributor.author | Altan, Feray | |
dc.contributor.author | Ipek, Duygu Neval Sayin | |
dc.contributor.author | Corum, Orhan | |
dc.contributor.author | Alp, Simten Yesilmen | |
dc.contributor.author | Ipek, Polat | |
dc.contributor.author | Uney, Kamil | |
dc.date.accessioned | 2024-04-24T16:02:23Z | |
dc.date.available | 2024-04-24T16:02:23Z | |
dc.date.issued | 2019 | |
dc.department | Dicle Üniversitesi | en_US |
dc.description.abstract | The study aimed to define the effects of M. haemolytica and a single oral dose of albendazole on the single-dose pharmacokinetics of marbofloxacin in lambs. The pharmacokinetic-pharmacodynamic integration of marbofloxacin was applied to describe a 3 mg/kg intramuscular dose in lambs. The 6 healthy and 12 naturally infected with M. haemolytica lambs (Akkaraman, males weighing 10-15 kg and aged 2-3 months) were used in this study. In the marbofloxacin group, 6 healthy lambs received marbofloxacin. In the albendazole group after 2 weeks washout period, the same animals received marbofloxacin on 1 h after albendazole. In the diseased marbofloxacin group, 6 lambs naturally infected with M. haemolytica received marbofloxacin. In the diseased albendazole group, 6 lambs naturally infected with M. haemolytica received marbofloxacin on 1 h after albendazole. The marbofloxacin and albendazole were administered each as a single dose of 3 mg/kg intramuscular and 7.5 mg/kg oral, respectively, in the respective groups. Plasma concentration of marbofloxacin was measured with HPLC-UV and pharmacokinetic parameters were analyzed by non-compartmental model. Albendazole did not change the pharmacokinetic profiles of marbofloxacin in healthy and diseased lambs. However, M. haemolytica affected the pharmacokinetics of marbofloxacin in diseased lambs, AUC(0-24)/MIC90 ratio was not found to be higher than 125, but C-max/MIC90 ratios was found to be higher than 10 for an MIC value of 0.25 mu g/mL in all groups. The marbofloxacin dose described in this study may not be effective for the treatment of infections due to M. haemolytica in lambs, with MIC <= 0.25 mu g/mL. | en_US |
dc.identifier.doi | 10.1007/s11250-019-01980-5 | |
dc.identifier.endpage | 2610 | en_US |
dc.identifier.issn | 0049-4747 | |
dc.identifier.issn | 1573-7438 | |
dc.identifier.issue | 8 | en_US |
dc.identifier.pmid | 31230255 | |
dc.identifier.scopus | 2-s2.0-85068128991 | |
dc.identifier.scopusquality | Q2 | |
dc.identifier.startpage | 2603 | en_US |
dc.identifier.uri | https://doi.org/10.1007/s11250-019-01980-5 | |
dc.identifier.uri | https://hdl.handle.net/11468/14773 | |
dc.identifier.volume | 51 | en_US |
dc.identifier.wos | WOS:000494799400057 | |
dc.identifier.wosquality | Q2 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.ispartof | Tropical Animal Health and Production | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Albendazole | en_US |
dc.subject | Lamb | en_US |
dc.subject | Mannheimia Haemolytica | en_US |
dc.subject | Marbofloxacin | en_US |
dc.subject | Pharmacokinetics | en_US |
dc.title | The effects of Mannheimia haemolytica and albendazole on marbofloxacin pharmacokinetics in lambs | en_US |
dc.title | The effects of Mannheimia haemolytica and albendazole on marbofloxacin pharmacokinetics in lambs | |
dc.type | Article | en_US |