Bioequivalence study of two long-acting oxytetracycline formulations in sheep

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dc.contributor.authorOzdemir, N.
dc.contributor.authorYildirim, M.
dc.date.accessioned2024-04-24T16:02:25Z
dc.date.available2024-04-24T16:02:25Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractTwo commercially available long-acting oxytetracycline hydrochloride formulations (Primamycin LA (Pfizer) and Terrallent 20% LA (I.E. Ulagay)) were administered by the intramuscular route to 20 clinically healthy sheep at a dose of 20 mg/kg. The study was performed in a two-period crossover design. Plasma samples were analysed by high-pressure liquid chromatography. The mean maximum concentrations (C-max) was 8.00 +/- 2.05 mu g/ml and 8.61 +/- 1.42 mu g/ml, respectively. The mean area under the concentration time curve (AUC) values were 154.95 +/- 50.37 (mu g h)/ml and 161.70 +/- 47.02 (mu g h)/ml, respectively. The 90% confidence intervals for the ratio of C-max and AUC values for the test and reference product are within the interval 70-143% for C-max and interval 80-125% for AUC proposed by EMEA. It was concluded that Primamycin LA and Terralent 20% LA formulations are bioequivalent in their rate and extent of drug absorbtion.en_US
dc.identifier.doi10.1007/s11259-006-3235-2
dc.identifier.endpage934en_US
dc.identifier.issn0165-7380
dc.identifier.issue8en_US
dc.identifier.pmid17139544
dc.identifier.scopus2-s2.0-33846682751
dc.identifier.scopusqualityQ2
dc.identifier.startpage929en_US
dc.identifier.urihttps://doi.org/10.1007/s11259-006-3235-2
dc.identifier.urihttps://hdl.handle.net/11468/14787
dc.identifier.volume30en_US
dc.identifier.wosWOS:000243193600012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofVeterinary Research Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioavailabilityen_US
dc.subjectBioequivalenceen_US
dc.subjectLong Actingen_US
dc.subjectSheepen_US
dc.subjectOxytetracyclineen_US
dc.titleBioequivalence study of two long-acting oxytetracycline formulations in sheepen_US
dc.titleBioequivalence study of two long-acting oxytetracycline formulations in sheep
dc.typeArticleen_US

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