Ga-68-FAPI-04 PET/CT, a new step in breast cancer imaging: a comparative pilot study with the F-18-FDG PET/CT

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dc.authorid0000-0002-7931-2941en_US
dc.contributor.authorKömek, Halil
dc.contributor.authorCan, Canan
dc.contributor.authorGüzel, Yunus
dc.contributor.authorOruç, Zeynep
dc.contributor.authorGündoğan, Cihan
dc.contributor.authorYıldırım, Özgen Ahmet
dc.contributor.authorKaplan, İhsan
dc.contributor.authorErdur, Erkan
dc.contributor.authorYıldırım, Mehmet Serdar
dc.contributor.authorCakabay, Bahri
dc.date.accessioned2022-08-18T12:12:47Z
dc.date.available2022-08-18T12:12:47Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Medikal Onkoloji Ana Bilim Dalıen_US
dc.descriptionWOS:000646096500001
dc.descriptionPMID: 33934311
dc.description.abstractAbstract Aim We aimed to compare the roles of Ga-68-FAPI-04 PET/CT and F-18-FDG PET/CT in the evaluation of primary tumor and metastases in primary and recurrent breast cancer. Materials and method Twenty female patients with histopathologically confirmed primary and recurrent breast cancer were included in the prospective study. All patients underwent FDG and FAPI PET/CT imaging in the same week. The number of primary and metastatic lesions, SUVmax values, and tumor-to-background ratios (TBR) were recorded from both scans. Data obtained were statistically compared. Results FAPI PET/CT was superior to FDG in detecting breast lesions, as well as hepatic, bone, lymph node, and cerebral metastases in terms of patient- and lesion-based assessments. The sensitivity and specificity of FAPI in detecting primary breast lesions were 100% and 95.6%, respectively, while the sensitivity and specificity of FDG were 78.2% and 100%, respectively. The SUVmax values of primary breast tumors, lymph nodes, lung metastases, and bone metastases were significantly higher on FAPI imaging than FDG imaging (p < 0.05). However, SUVmax values of hepatic metastases did not exhibit a statistically significant difference between two imaging techniques (p > 0.05). Also, FAPI imaging yielded significantly higher TBR in breast lesions as well as hepatic, bone, brain and lung metastases compared to FDG (p < 0.05). Conclusion (68) Ga-FAPI-04 PET/CT is superior to F-18-FDG PET/CT in detecting the primary tumor in patients with breast cancer with its high sensitivity, high SUVmax, and high TBR. (68) Ga-FAPI-04 PET/CT is also superior to F-18-FDG PET/CT in detecting lymph node, hepatic, bone, and cerebral metastases because it has lower background activity and higher uptake in subcentimetric lesions.en_US
dc.identifier.citationKömek, H., Can, C.N., Güzel, Y., Oruç, Z., Gündoğan, C., Yıldırım, Ö.A. ve diğerleri (2021). Ga-68-FAPI-04 PET/CT, a new step in breast cancer imaging: a comparative pilot study with the F-18-FDG PET/CT. Annals of Nuclear Medicine, 35(6), 744-752. https://doi.org/10.1007/s12149-021-01616-5en_US
dc.identifier.doi10.1007/s12149-021-01616-5
dc.identifier.endpage752en_US
dc.identifier.issn0914-7187
dc.identifier.issn1864-6433
dc.identifier.issue6en_US
dc.identifier.pmid33934311
dc.identifier.scopus2-s2.0-85105369340
dc.identifier.scopusqualityQ2
dc.identifier.startpage744en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s12149-021-01616-5
dc.identifier.urihttps://hdl.handle.net/11468/10208
dc.identifier.volume35en_US
dc.identifier.wosWOS:000646096500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOruç, Zeynep
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals of Nuclear Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectF-18-FDGen_US
dc.subject(68) Ga-FAPIen_US
dc.subjectPET/CTen_US
dc.titleGa-68-FAPI-04 PET/CT, a new step in breast cancer imaging: a comparative pilot study with the F-18-FDG PET/CTen_US
dc.titleGa-68-FAPI-04 PET/CT, a new step in breast cancer imaging: a comparative pilot study with the F-18-FDG PET/CT
dc.typeArticleen_US

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