Factor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkey

Basit Öğe Kaydı
dc.contributor.authorAltintas, Abdullah
dc.contributor.authorPasa, Semir
dc.contributor.authorAkdeniz, Nurten
dc.contributor.authorCil, Timucin
dc.contributor.authorYurt, Murat
dc.contributor.authorAyyildiz, Orhan
dc.contributor.authorBatun, Sabri
dc.date.accessioned2024-04-24T16:00:02Z
dc.date.available2024-04-24T16:00:02Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractFactor V Leiden (FV-Leiden) and prothrombin gene mutations (FII G20210A) are well-established independent risk factors for thrombosis. In the recent years, many studies have suggested that these mutations are associated with an increased risk of recurrent pregnancy loss (RPL). We aimed to investigate the prevalence of these molecular defects in subjects with a history of early RPL. One hundred and fourteen women with three or more consecutive unexplained first-trimester miscarriages were compared to 185 parous women with uncomplicated pregnancies from the same ethnic origin. The presence of FV-Leiden and FII G20210A mutations was assessed by polymerase chain reaction analysis. Overall, 11 out of the 114 women with early RPL (9.6%) had either FV-Leiden or FII G20210A mutation, as compared with 16 out of the 185 women with normal pregnancies (8.6%; p=0.756). The prevalence of FV-Leiden mutation was 7.9% (9/114) in patient group, compared with 7% (13/185) in control group (p=0.780). One hundred and two patients were primary and 12 were secondary aborters. All FV-Leiden positive cases were primary aborters (8.8%; 9/102, p=0.584). Concerning the FII G20210A, two out of 114 (1.7%) were first-trimester RPL (primary aborters) and three out of 185 (1.6%) controls were carriers of the FII G20210A mutation (1.7 vs 1.6%, p=0.931). The results obtained from patients with first-trimester RPL and the control group have no statistical significant differences in the prevalence of FV-Leiden and FII G20210A mutations. These results suggest that mutations have no role in etiology of first-trimester recurrent abortions.en_US
dc.identifier.doi10.1007/s00277-007-0327-1
dc.identifier.endpage731en_US
dc.identifier.issn0939-5555
dc.identifier.issue10en_US
dc.identifier.pmid17572893
dc.identifier.scopus2-s2.0-34548303853
dc.identifier.scopusqualityQ2
dc.identifier.startpage727en_US
dc.identifier.urihttps://doi.org/10.1007/s00277-007-0327-1
dc.identifier.urihttps://hdl.handle.net/11468/14347
dc.identifier.volume86en_US
dc.identifier.wosWOS:000248975000005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals of Hematology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRecurrent Pregnancy Lossen_US
dc.subjectFactor V Leidenen_US
dc.subjectFii G20210aen_US
dc.titleFactor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkeyen_US
dc.titleFactor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkey
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu