Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle

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dc.contributor.authorAydin, Suna
dc.contributor.authorKuloglu, Tuncay
dc.contributor.authorAydin, Suleyman
dc.contributor.authorEren, Mehmet Nesimi
dc.contributor.authorCelik, Ahmet
dc.contributor.authorYilmaz, Musa
dc.contributor.authorKalayci, Mehmet
dc.date.accessioned2024-04-24T16:15:48Z
dc.date.available2024-04-24T16:15:48Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractIrisin converts white adipose tissue (WAT) into brown adipose tissue (BAT), as regulated by energy expenditure. The relationship between irisin concentrations after exercise in rats compared humans after exercise remains controversial. We therefore: (1) measured irisin expression in cardiac and skeletal muscle, liver, kidney, peripheral nerve sheath and skin tissues, as also serum irisin level in 10 week-old rats without exercise, and (2) measured tissue supernatant irisin levels in cardiac and skeletal muscle, and in response to exercise in young and old rats to establishing which tissues produced most irisin. Young (12 months) and old rats (24 months) with or without 10min exercise (water floating) and healthy 10 week-old Sprague-Dawley rats without exercise were used. Irisin was absent from sections of skeletal muscle of unexercised rats, the only part being stained being the perimysium. In contrast, cardiac muscle tissue, peripheral myelin sheath, liver, kidneys, and skin dermis and hypodermis were strongly immunoreactivity. No irisin was seen in skeletal muscle of unexercised young and old rats, but a slight amount was detected after exercise. Strong immunoreactivity occurred in cardiac muscle of young and old rats with or without exercise, notably in pericardial connective tissue. Serum irisin increased after exercise, being higher in younger than older rats. Irisin in tissue supernatants (cardiac and skeletal muscle) was high with or without exercise. High supernatant irisin could come from connective tissues around skeletal muscle, especially nerve sheaths located within it. Skeletal muscle is probably not a main irisin source. Copyright (C) 2013 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.peptides.2013.11.024
dc.identifier.endpage73en_US
dc.identifier.issn0196-9781
dc.identifier.issn1873-5169
dc.identifier.pmid24345335
dc.identifier.scopus2-s2.0-84891598333
dc.identifier.scopusqualityQ2
dc.identifier.startpage68en_US
dc.identifier.urihttps://doi.org/10.1016/j.peptides.2013.11.024
dc.identifier.urihttps://hdl.handle.net/11468/15930
dc.identifier.volume52en_US
dc.identifier.wosWOS:000333275400012
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofPeptides
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIrisinen_US
dc.subjectCardiac And Skeletal Muscleen_US
dc.subjectSkinen_US
dc.subjectNerve Sheathen_US
dc.subjectLiveren_US
dc.subjectKidneyen_US
dc.titleCardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscleen_US
dc.titleCardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle
dc.typeArticleen_US

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