Effect of erythropoietin on liver regeneration in an experimental model of partial hepatectomy

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dc.contributor.authorGul, Mesut
dc.contributor.authorComert, Mustafa
dc.contributor.authorCakmak, Guldeniz Karadeniz
dc.contributor.authorKertis, Gurkan
dc.contributor.authorUgurbas, Ebru
dc.contributor.authorOner, Muzaffer Onder
dc.date.accessioned2024-04-24T16:14:55Z
dc.date.available2024-04-24T16:14:55Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and aim: The liver shows remarkable regeneration ability after damage or resection. The main stimulant for hepatic regeneration is resection. Erythropoietin (EPO), which was initially used for anemia therapy, is today known as a general tissue protector owing to its anti-inflammatory, antioxidant, anti-apoptotic, and angiogenic properties. This study aims to investigate the effect of systemically administered EPO on liver regeneration after partial hepatectomy. Methods: Forty-eight male Wistar albino rats were randomly split in two groups A and B consisting of 24 rats each. Standard 70% hepatectomy was performed on the rats in group A. The same surgical procedure was performed on the rats in group B, and they were additionally administered 3000 U/kg/subcutaneous EPO. The rats were sacrificed 24, 48, and 72 h after resection. The groups were compared in terms of biochemical, morphological, and histopathological parameters. Results: The biochemical results showed that the administration of EPO decreased aspartate aminotransferase levels significantly (p < 0.05) at 24 h after hepatectomy. A comparison of the groups in terms of relative liver weight showed that EPO-treated groups exhibited a statistically significant increase (p < 0.05) for all three time periods. Histopathology results showed that in the EPO-treated groups, the mitosis index at 48 and 72 h, double nuclei cell number at 72 h, and proliferating cell nuclear antigen ratio at 48 h showed a significant increase (p < 0.05). Conclusion: Our study showed that systemically administering high-dose EPO increases regeneration by affecting the biochemical, morphological, and histopathological parameters after liver resection. (C) 2012 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijsu.2012.11.012
dc.identifier.endpage63en_US
dc.identifier.issn1743-9191
dc.identifier.issn1743-9159
dc.identifier.issue1en_US
dc.identifier.pmid23211135
dc.identifier.scopus2-s2.0-84872606957
dc.identifier.scopusqualityQ1
dc.identifier.startpage59en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijsu.2012.11.012
dc.identifier.urihttps://hdl.handle.net/11468/15520
dc.identifier.volume11en_US
dc.identifier.wosWOS:000316936600013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPartial Hepatectomyen_US
dc.subjectLiver Regenerationen_US
dc.subjectErythropoietinen_US
dc.titleEffect of erythropoietin on liver regeneration in an experimental model of partial hepatectomyen_US
dc.titleEffect of erythropoietin on liver regeneration in an experimental model of partial hepatectomy
dc.typeArticleen_US

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