Identifying autonomic nervous system dysfunction in acute cerebrovascular attack by assessments of heart rate variability and catecholamine levels

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dc.contributor.authorAkil, Esref
dc.contributor.authorTamam, Yusuf
dc.contributor.authorAkil, Mehmet Ata
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorBilik, Mehmet Zihni
dc.contributor.authorAcar, Abdullah
dc.contributor.authorTamam, Banu
dc.date.accessioned2024-04-24T17:24:13Z
dc.date.available2024-04-24T17:24:13Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: This study aimed to evaluate changes in the autonomic nervous system caused by cerebral lesions due to acute stroke. We assessed heart rate variability and catecholamine levels in lieu of stroke lesion localization. Materials and Methods: A total of 60 stroke patients and 31 healthy controls were enrolled in the study. Plasma epinephrine and norepinephrine levels were measured on the first, third, and seventh days following the stroke event. Heart rate variability was evaluated with time-domain and frequency-domain analyses via 24-hour Holter monitor recordings. Results: On the first and third day following the stroke, norepinephrine levels were significantly higher in all patient groups as compared to controls. Epinephrine levels on the first, third and seventh days after the stroke were significantly higher in patients with lesions in the right middle cerebral artery territory than controls. In frequency-domain analysis, patients with right middle cerebral artery territory lesions had greater low frequency and low frequency to high frequency ratio values than controls. Time-domain analysis revealed significant decreases in the standard deviation from the mean for 5-minute 288 R-R intervals in patients with lesions in the right middle cerebral artery and posterior cerebral artery territory when contrasted with controls. Patients with lesions in the right middle cerebral artery territory demonstrated the highest increase in the percentage of consecutive R-R intervals differing by more than 50 ms (pNN50) as compared to the control group. Conclusion: These findings indicate that autonomic dysfunction favoring an increase in sympathetic activity occurs in acute stroke patients.en_US
dc.description.sponsorshipDicle University DUBAPen_US
dc.description.sponsorshipWe are grateful to Dicle University DUBAP for their sponsorship about English editing of this manuscript.en_US
dc.identifier.doi10.4103/0976-3147.153216
dc.identifier.endpage+en_US
dc.identifier.issn0976-3147
dc.identifier.issn0976-3155
dc.identifier.issue2en_US
dc.identifier.pmid25883469
dc.identifier.scopus2-s2.0-84925737077
dc.identifier.scopusqualityQ3
dc.identifier.startpage145en_US
dc.identifier.urihttps://doi.org/10.4103/0976-3147.153216
dc.identifier.urihttps://hdl.handle.net/11468/19534
dc.identifier.volume6en_US
dc.identifier.wosWOS:000218656000006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofJournal of Neurosciences in Rural Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutonomic Nervous Systemen_US
dc.subjectCatecholaminesen_US
dc.subjectHeart Rate Variabilityen_US
dc.subjectStrokeen_US
dc.titleIdentifying autonomic nervous system dysfunction in acute cerebrovascular attack by assessments of heart rate variability and catecholamine levelsen_US
dc.titleIdentifying autonomic nervous system dysfunction in acute cerebrovascular attack by assessments of heart rate variability and catecholamine levels
dc.typeArticleen_US

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