Effects of methoctramine on bladder overactivity in a rat model

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dc.contributor.authorÖztürk, H
dc.contributor.authorOnen, A
dc.contributor.authorGuneli, E
dc.contributor.authorCicek, R
dc.contributor.authorHekimoglu, AT
dc.date.accessioned2024-04-24T16:18:43Z
dc.date.available2024-04-24T16:18:43Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives. To determine the functional effects of methoctramine as an M-2 muscarinic receptor antagonist on isolated detrusor strips in vitro and bladder overactivity in vivo in rats. Methods. A total of 114 Sprague-Dawley rats were used in the present study. Isolated rat detrusor strips were contracted by depolarizing the preparations with carbachol. Methoctramine was added to the tissue bath in increasing concentrations, and contraction inhibition was assessed. Isovolumetric contractions were evoked by electrical stimulation using a bipolar electrode. Efficacy against bladder instability was evaluated using the obstructed hypertrophied bladder model in the rat. The acetic acid bladder cystometry model was used to assess the efficacy of methoctramine in neurogenic detrusor overactivity. Results. Methoctramine inhibited carbachol-induced bladder contractions significantly in isolated rat detrusor strips in a concentration-dependent manner. The amplitude of electrically evoked isovolumetric contractions was decreased significantly after methoctramine exposure. In vivo methoctramine administered intravenously significantly increased the voiding interval and bladder compliance. In addition, a decrease occurred in the number of spontaneous contractions during the filling phase in a model of neurogenic and obstruction-induced detrusor overactivity. Conclusions. M-2 antagonists in general may represent a new useful class of drug worth considering in the treatment of bladder overactivity. (C) 2003, Elsevier Science Inc.en_US
dc.identifier.doi10.1016/S0090-4295(02)02260-4
dc.identifier.endpage676en_US
dc.identifier.issn0090-4295
dc.identifier.issue3en_US
dc.identifier.pmid12639681
dc.identifier.scopus2-s2.0-0037333566
dc.identifier.scopusqualityQ2
dc.identifier.startpage671en_US
dc.identifier.urihttps://doi.org/10.1016/S0090-4295(02)02260-4
dc.identifier.urihttps://hdl.handle.net/11468/16249
dc.identifier.volume61en_US
dc.identifier.wosWOS:000181928200042
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEffects of methoctramine on bladder overactivity in a rat modelen_US
dc.titleEffects of methoctramine on bladder overactivity in a rat model
dc.typeArticleen_US

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