The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group

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dc.authorid0000000213312906en_US
dc.contributor.authorTurgutalp, Kenan
dc.contributor.authorCebeci, Egemen
dc.contributor.authorTürkmen, Aydın
dc.contributor.authorDerici, Ülver Boztepe
dc.contributor.authorSeyahi, Nurhan
dc.contributor.authorEren, Necmi
dc.contributor.authorDede, Fatih
dc.contributor.authorGüllülü, Mustafa
dc.contributor.authorBaştürk, Taner
dc.contributor.authorŞahin, Gülizar Manga
dc.contributor.authorYılmaz, Mürvet
dc.contributor.authorSipahi, Savaş
dc.contributor.authorŞahin, Garip
dc.contributor.authorUlu, Sena Memnune
dc.contributor.authorTatar, Erhan
dc.contributor.authorGündogdu, Ali
dc.contributor.authorKazancıoğlu, Rümeyza Turan
dc.contributor.authorSevinç, Can
dc.contributor.authorGüngör, Özkan
dc.contributor.authorŞahin, İdris
dc.contributor.authorKutlay, Sim
dc.contributor.authorKurultak, İlhan
dc.contributor.authorAydın, Zeki
dc.contributor.authorAltun, Bülent
dc.contributor.authorDursun, Belda
dc.contributor.authorYılmaz, Zülfükar
dc.contributor.authorUzun, Özcan
dc.contributor.authorSüleymanlar, Gültekin
dc.contributor.authorCandan, Ferhan
dc.contributor.authorSezer, Siren
dc.contributor.authorTanburoğlu, Derya Basak
dc.contributor.authorBicik, Zerrin
dc.contributor.authorTaymez, Dilek Güven
dc.contributor.authorAkcali, Esra
dc.contributor.authorOygar, Düriye Deren
dc.contributor.authorİstemihan, Zülal
dc.contributor.authorBardak, Simge
dc.contributor.authorBardak, Simge
dc.contributor.authorAkçay, Ömer Faruk
dc.contributor.authorDincer, Mevlüt Tamer
dc.contributor.authorDervişoğlu, Erkan
dc.contributor.authorYenigün, Ezgi Çoşkun
dc.contributor.authorTürkmen, Kültigin
dc.contributor.authorÖzturk, Savaş
dc.date.accessioned2022-03-04T11:13:54Z
dc.date.available2022-03-04T11:13:54Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.descriptionPMID: 34711174
dc.description.abstractBackground: Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods: A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results: 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = − 0.084, r = − 0.102, r = − 0.006, r = 0.062, r = 0.014, r = − 0.044, r = − 0.061, r = − 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion: Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors.en_US
dc.identifier.citationTurgutalp, K., Cebeci, E., Türkmen, A., Derici, Ü. B., Seyahi, N., Eren, N. ve diğerleri. (2021). The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group. BMC Nephrology, 22(1), 352.en_US
dc.identifier.doi10.1186/s12882-021-02560-2
dc.identifier.issn1471-2369
dc.identifier.issue1en_US
dc.identifier.pmid34711174
dc.identifier.scopus2-s2.0-85117893002
dc.identifier.scopusqualityQ2
dc.identifier.startpage352en_US
dc.identifier.urihttps://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-021-02560-2
dc.identifier.urihttps://hdl.handle.net/11468/9323
dc.identifier.volume22en_US
dc.identifier.wosWOS:000712386500002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Zülfükar
dc.language.isoenen_US
dc.publisherBioMed Central Ltden_US
dc.relation.ispartofBMC Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlomerular IgG stainingen_US
dc.subjectIgA nephropathyen_US
dc.subjectRenal prognostic factorsen_US
dc.titleThe relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working groupen_US
dc.titleThe relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group
dc.typeArticleen_US

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