The Effect of Hyperbaric Oxygen Treatment on the Healing of Burn Wounds in Nicotinized and Nonnicotinized Rats

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dc.contributor.authorSelcuk, Caferi Tayyar
dc.contributor.authorOzalp, Burhan
dc.contributor.authorDurgun, Mustafa
dc.contributor.authorTekin, Alicem
dc.contributor.authorAkkoc, Mehmet Fatih
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorIlgezdi, Savas
dc.date.accessioned2024-04-24T17:08:15Z
dc.date.available2024-04-24T17:08:15Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe importance of oxygen in wound healing and the negative effects of cigarette smoking have been demonstrated in various studies. In this study, our aim was to investigate the effect of hyperbaric oxygen (HBO2) treatment on wound healing in nicotinized and nonnicotinized rats. The study was conducted on 32 Sprague Dawley rats. The rats were divided into four groups, with eight rats in each: group 1, nonnicotinized rats; group 2, nonnicotinized rats treated with HBO2; group 3, nicotinized rats; and group 4, nicotinized rats treated with HBO2. To prepare the nicotinized groups, the rats were given nicotine for 28 days. At the end of day 28, standard, deep, second-degree to third-degree burns were created on the rats. The HBO2-treated groups underwent HBO2 treatment once a day for 7 days after the creation of the burn damage. All rats were killed 21 days after injury, and the burns were subjected to macroscopic, histopathological, and microbiological evaluation. During this evaluation, the smallest necrotic areas and the lowest rate of fibrosis were observed in group 2. The largest necrotic areas and the highest inflammation and fibrosis rates were observed in the nicotine-treated group 3. When the nicotinized and nonnicotinized groups were compared separately, there was a significant difference in favor of the groups treated with HBO2. Bacterial growth was the highest in the nicotinized group 3, whereas no statistically significant difference was observed among the other groups. We conclude that HBO treatment accelerates the recovery of burn wounds and provides more effective healing by reducing the development of scars both in nicotinized and nonnicotinized rats.en_US
dc.identifier.doi10.1097/BCR.0b013e318270092e
dc.identifier.endpageE243en_US
dc.identifier.issn1559-047X
dc.identifier.issn1559-0488
dc.identifier.issue4en_US
dc.identifier.pmid23271059
dc.identifier.scopus2-s2.0-84881158558
dc.identifier.scopusqualityQ2
dc.identifier.startpageE237en_US
dc.identifier.urihttps://doi.org/10.1097/BCR.0b013e318270092e
dc.identifier.urihttps://hdl.handle.net/11468/17268
dc.identifier.volume34en_US
dc.identifier.wosWOS:000330464500005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofJournal of Burn Care & Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe Effect of Hyperbaric Oxygen Treatment on the Healing of Burn Wounds in Nicotinized and Nonnicotinized Ratsen_US
dc.titleThe Effect of Hyperbaric Oxygen Treatment on the Healing of Burn Wounds in Nicotinized and Nonnicotinized Rats
dc.typeArticleen_US

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