Oxidative stress index may play a key role in patients with pemphigus vulgaris

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dc.contributor.authorYesilova, Y.
dc.contributor.authorUcmak, D.
dc.contributor.authorSelek, S.
dc.contributor.authorDertlioglu, S. B.
dc.contributor.authorSula, B.
dc.contributor.authorBozkus, F.
dc.contributor.authorTuran, E.
dc.date.accessioned2024-04-24T17:11:35Z
dc.date.available2024-04-24T17:11:35Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground Increased reactive oxygen species (ROS) and lipid peroxidation are seen in many dermatologic disorders, including atopic dermatitis, psoriasis, vitiligo, acne vulgaris, pemphigus vulgaris (PV), lichen planus and alopecia areata. In PV, the increased production of ROS from activated neutrophils reduces the concentrations of antioxidant vitamins and enzymes. Objective The present study aims to determine the oxidative stress index (OSI) by studying serum total oxidant capacity (TOC), lipid hydroperoxide (LOOH) and total antioxidant capacity (TAC) in PV patients. Methods The study included 27 PV patients and a control group consisting of 24 healthy volunteers. Serum TOC, LOOH and TAC levels were examined and OSI was measured in the PV patients and the control group. Results TOC (P=0.001) and LOOH (P=0.001) levels as well as OSI (P=0.001) were found higher in the PV patients, relative to the control group. Serum TAS (P=0.221) did not differ between groups. Serum TOC, LOOH and TAC levels and OSI in PV patients with mucosal involvement were not different than those in mucocutaneous PV patients. Conclusion Serum TOC and LOOH levels and OSI were higher in the PV patients, in comparison with the control group. Serum TAC level was not different.en_US
dc.identifier.doi10.1111/j.1468-3083.2012.04463.x
dc.identifier.endpage467en_US
dc.identifier.issn0926-9959
dc.identifier.issn1468-3083
dc.identifier.issue4en_US
dc.identifier.pmid22324759
dc.identifier.scopus2-s2.0-84875370061
dc.identifier.scopusqualityQ1
dc.identifier.startpage465en_US
dc.identifier.urihttps://doi.org/10.1111/j.1468-3083.2012.04463.x
dc.identifier.urihttps://hdl.handle.net/11468/17622
dc.identifier.volume27en_US
dc.identifier.wosWOS:000316575200009
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of The European Academy of Dermatology and Venereology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleOxidative stress index may play a key role in patients with pemphigus vulgarisen_US
dc.titleOxidative stress index may play a key role in patients with pemphigus vulgaris
dc.typeArticleen_US

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