Evaluation of protein levels of autophagy markers (Beclin 1 and SQSTM1/p62) and phosphorylation of cyclin E in the placenta of women with preeclampsia

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dc.contributor.authorYildiz, Dilara Akcora
dc.contributor.authorKandemir, Sevgi Irtegun
dc.contributor.authorAgacayak, Elif
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:17:57Z
dc.date.available2024-04-24T17:17:57Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractPreeclampsia is a severe multisystem disorder, and its pathophysiology is still not completely understood. Autophagy, a recycling process that maintains cellular homoeostasis during differentiation and development, is controversial regarding increased or decreased autophagic activity in preeclampsia. The aim of this study was to determine whether autophagy is increased in the placentas of women with preeclampsia by examining the protein levels of autophagy markers (Beclin 1 and SQSTM1/p62) and phosphorylation of cyclin E. For this purpose, placentas from preeclampsia (n=10) and control (n=10) pregnancies were included in this study. The protein expression of autophagy-related markers Beclin1, SQSTM1/p62 and phosphorylation status of cyclin E were detected by Western blot. Our data showed that the protein levels of both Beclin 1 and SQSTM1/p62 were significantly increased, while the phosphorylation level of cyclin E was significantly decreased in placentas with preeclampsia compared to those derived from controls. The results of this study suggest that the autophagic activity is perpetually increased in preeclampsia and cyclin E protein stabilisation might be involved in the induction of autophagy.en_US
dc.identifier.doi10.14715/cmb/2017.63.12.12
dc.identifier.endpage55en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue12en_US
dc.identifier.pmid29307342
dc.identifier.scopus2-s2.0-85039981948
dc.identifier.scopusqualityQ4
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2017.63.12.12
dc.identifier.urihttps://hdl.handle.net/11468/18469
dc.identifier.volume63en_US
dc.identifier.wosWOS:000419272800012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherC M B Assocen_US
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectPlacentaen_US
dc.subjectBeclin 1en_US
dc.subjectSqstm1/P62en_US
dc.subjectCyclin Een_US
dc.titleEvaluation of protein levels of autophagy markers (Beclin 1 and SQSTM1/p62) and phosphorylation of cyclin E in the placenta of women with preeclampsiaen_US
dc.titleEvaluation of protein levels of autophagy markers (Beclin 1 and SQSTM1/p62) and phosphorylation of cyclin E in the placenta of women with preeclampsia
dc.typeArticleen_US

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