Development of starch based mucoadhesive vaginal drug delivery systems for application in veterinary medicine

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dc.contributor.authorGok, Mehmet Koray
dc.contributor.authorOzgumus, Saadet
dc.contributor.authorDemir, Kamber
dc.contributor.authorCirit, Umut
dc.contributor.authorPabuccuoglu, Serhat
dc.contributor.authorCevher, Erdal
dc.contributor.authorOzsoy, Yildiz
dc.date.accessioned2024-04-24T16:10:59Z
dc.date.available2024-04-24T16:10:59Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to prepare and evaluate the mucoadhesive, biocompatible and biodegradable progesterone containing vaginal tablets based on modified starch copolymers for the estrus synchronization of ewes. Starch-graft-poly( acrylic acid) copolymers (S-g-PAA) were synthesized and characterized. The vaginal tablets were fabricated with S-g-PAA and their equilibrium swelling degree (Qe) and matrix erosion (ME%) were determined in lactate buffer solution. In vitro, mucoadhesive properties of the tablets were investigated by using ewe vaginal mucosa and in vivo residence time were also investigated. In vitro and in vivo progesterone release profiles from the tablets were compared with two commercial products. Tablet formulation containing wheat starch based grafted copolymer (WS-g-PAA)(gc) indicated promising results and might be convenient as an alternative product to the commercial products in veterinary medicine. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University [594/15122006, 8585]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Projects Coordination Unit of Istanbul University, Project Number 594/15122006 and 8585. Tablet formulation which was developed patented by the Turkish Patent Institue (TR 2012 03191 B, May 2015) and to be a patent applied the European Patent Office (19.03.2013-EP13160042.1). We would like to thank Prof. Dr. Ugur Ozbek, Prof. Dr. Duran Ostek and Dr. Aris Cakiris from Institute of Experimental Medicine of Istanbul University for their help in cytotoxicity assays.en_US
dc.identifier.doi10.1016/j.carbpol.2015.08.079
dc.identifier.endpage70en_US
dc.identifier.issn0144-8617
dc.identifier.issn1879-1344
dc.identifier.pmid26572329
dc.identifier.scopus2-s2.0-84941711671
dc.identifier.scopusqualityQ1
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2015.08.079
dc.identifier.urihttps://hdl.handle.net/11468/15221
dc.identifier.volume136en_US
dc.identifier.wosWOS:000365972000008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofCarbohydrate Polymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVaginal Drug Deliveryen_US
dc.subjectMucoadhesionen_US
dc.subjectStarchen_US
dc.subjectAcrylic Aciden_US
dc.subjectProgesteroneen_US
dc.subjectEstrus Synchronizationen_US
dc.titleDevelopment of starch based mucoadhesive vaginal drug delivery systems for application in veterinary medicineen_US
dc.titleDevelopment of starch based mucoadhesive vaginal drug delivery systems for application in veterinary medicine
dc.typeArticleen_US

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